CT scans of Egyptian mummies reveal oldest known cases of breast cancer and multiple myeloma

(University of Granada) An international research team has established that the woman with breast cancer died around 2000 B.C., while the man with multiple myeloma died around 1800 B.C.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Genomics and Health Disparities Lecture Series John Carpten, PhD is Professor and Chair for the Department of Translational Genomics. His training and professional experiences include postdoctoral training at the National Human Genome Research Institute/NIH, and serving as Deputy Director of Research at the Translational Genomics Research Institute (TGen). Dr. Carpten ’ cancer research program spans multiple disciplines including germline genetics for disease risk and predisposition, somatic cancer genomics, health disparities research, cell biology, functional genomics, and precision medicine. The primary focus of h...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpitations. An abdominopelvic computed tomography (CT) scan was performed, showing multiple osteolytic lesions distributed in all bone structures and axillary adenopathy on the left side. As part of the approach and given the high suspicion of multiple myeloma, tests were perfor...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Abstract The management of bone lesions from advanced solid tumors and multiple myeloma typically includes use of a bone-modifying agent to reduce the risk of skeletal-related events. Recent data demonstrate that when using zoledronic acid to reduce the risk of skeletal-related events in metastatic breast cancer, metastatic prostate cancer, and multiple myeloma, the dosing interval of zoledronic acid may be extended from every 4 weeks to every 12 weeks. The ASCO guidelines on the role of bone-modifying agents in metastatic breast cancer and multiple myeloma address zoledronic acid dosing intervals. Herein, we disc...
Source: JOP - Category: Gastroenterology Authors: Tags: J Oncol Pract Source Type: research
Conclusions: HIF-2 α expression may be associated with the carcinogenesis of CRC, which is higher in males than in females, negatively linked to tumor differentiation, and correlated with a worse DFS of CRC. Additional prospective studies are needed.Cell Physiol Biochem 2018;48:516 –527
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: Available online 5 April 2018Source: Acta Pharmaceutica Sinica BAuthor(s): Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang, Minhao WuAbstractChimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR). The CAR-T cell is an effector T cell that recognizes and eliminates specific cancer cells, independent of major histocompatibility complex molecules. The whole procedure of CAR-T cell production is not well understood. The CAR-T cell has been used predominantly in t...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
In this study, we analysed the level of CD222 present in body fluids, namely in serum and urine, of cancer patients. We found significantly elevated levels of soluble CD222 in sera of cancer patients compared to healthy controls irrespective of the type of disease. The urine CD222 levels were increased specifically in breast cancer and multiple myeloma. In contrast to serum, CD222 was present within CD222-positive exosomes in urine pointing to different origins of CD222 present in various human body fluids. Based on this work, we propose serum soluble CD222 as a general biomarker for tumorigenesis. PMID: 29940770 [Pub...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
In a first, a national cancer organization has issued formal guidelines recommending exercise as part of cancer treatment, for all cancer patients. The Clinical Oncology Society of Australia (COSA) is very clear on the directive. Its recommendations are: Exercise should be embedded as part of standard practice in cancer care and viewed as an adjunct therapy that helps counteract the adverse effects of cancer and its treatment. All members of the multi-disciplinary cancer team should promote physical activity and help their patients adhere to exercise guidelines. Best practice cancer care should include referral to an accr...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Exercise and Fitness Health Source Type: blogs
Abstract Transfer learning (TL) algorithms aim to improve the prediction performance in a target task (e.g. the prediction of cisplatin sensitivity in triple-negative breast cancer patients) via transferring knowledge from auxiliary data of a related task (e.g. the prediction of docetaxel sensitivity in breast cancer patients), where the distribution and even the feature space of the data pertaining to the tasks can be different. In real-world applications, we sometimes have a limited training set in a target task while we have auxiliary data from a related task. To obtain a better prediction performance in the ta...
Source: Journal of Bioinformatics and Computational Biology - Category: Bioinformatics Authors: Tags: J Bioinform Comput Biol Source Type: research
Abstract INTRODUCTION: Cluster of differentiation 147 (CD147) contributes to breast cancer invasion, metastasis, and multidrug resistance. Recent studies have shown that peripheral soluble CD147 (sCD147) is increased in hepatocellular tumour and multiple myeloma patients and correlated with disease severity. The primary aim of our study was to assess the level, as well as the biological and clinical significance of sCD147 in breast cancer. METHODS: We tested plasma sCD147 levels in 308 breast cancer patients by enzyme-linked immunosorbent assay between February 2014 and February 2017. A subset of 165 cases of...
Source: Hong Kong Med J - Category: General Medicine Authors: Tags: Hong Kong Med J Source Type: research
This article summarizes the results of 30 y of follow-up of cancer and noncancer effects in Ukrainian cleanup workers after the Chornobyl accident. The number of power plant employees and first responders with acute radiation syndrome under follow-up by the National Research Center for Radiation Medicine decreased from 179 in 1986–1991 to 105 in 2011–2015. Cancers and leukemia (19) and cardiovascular diseases (21) were the main causes of deaths among acute radiation syndrome survivors (54) during the postaccident period. Increased radiation risks of leukemia in the Ukrainian cohort of 110,645 cleanup workers ex...
Source: Health Physics - Category: Radiology Tags: Review Papers Source Type: research
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