CT scans of Egyptian mummies reveal oldest known cases of breast cancer and multiple myeloma

(University of Granada) An international research team has established that the woman with breast cancer died around 2000 B.C., while the man with multiple myeloma died around 1800 B.C.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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This article summarizes the results of 30 y of follow-up of cancer and noncancer effects in Ukrainian cleanup workers after the Chornobyl accident. The number of power plant employees and first responders with acute radiation syndrome under follow-up by the National Research Center for Radiation Medicine decreased from 179 in 1986–1991 to 105 in 2011–2015. Cancers and leukemia (19) and cardiovascular diseases (21) were the main causes of deaths among acute radiation syndrome survivors (54) during the postaccident period. Increased radiation risks of leukemia in the Ukrainian cohort of 110,645 cleanup workers ex...
Source: Health Physics - Category: Radiology Tags: Review Papers Source Type: research
This article summarizes the results of 30 y of follow-up of cancer and noncancer effects in Ukrainian cleanup workers after the Chornobyl accident. The number of power plant employees and first responders with acute radiation syndrome under follow-up by the National Research Center for Radiation Medicine decreased from 179 in 1986-1991 to 105 in 2011-2015. Cancers and leukemia (19) and cardiovascular diseases (21) were the main causes of deaths among acute radiation syndrome survivors (54) during the postaccident period. Increased radiation risks of leukemia in the Ukrainian cohort of 110,645 cleanup workers exposed to low...
Source: Health Physics - Category: Physics Authors: Tags: Health Phys Source Type: research
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Breast Cancer Commentaries Source Type: research
Publication date: July 2018 Source:Journal of Fluorine Chemistry, Volume 211 Author(s): Larisa Politanskaya, Tatyana Rybalova, Olga Zakharova, Georgy Nevinsky, Evgeny Tretyakov Biologically interesting polyfluorinated 2-aryl-2,3-dihydroquinolin-4-ones (5), 3-benzylidene-2-aryl-2,3-dihydroquinolin-4-ones (6) and 7-methyl-6-aryl-5,6-dihydrodibenzo[b,h][1,6] naphthyridines (7) were synthesized using a mild and efficient one-pot procedure starting from 2-aminoacetophenones and trifluorobenzaldehyde in the presence of p-toluenesulfonic acid. Thanks to the use of a high-active polyfluorinated electrophile this synthetic protoco...
Source: Journal of Fluorine Chemistry - Category: Chemistry Source Type: research
Conclusions: Smoking increased the overall risk of cancer in primary care practices in the UK. In addition, smoking was predominantly positively and less frequently negatively associated with numerous specific cancers. PMID: 29707117 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) worsens oral health-related quality of life. Most BRONJ occurs in multiple myeloma or metastatic breast cancer patients treated with bisphosphonate/chemotherapeutic combination therapies. Cyclophosphamide (CY), an alkylating chemotherapeutic drug, is used to treat multiple myeloma, although its use has been recently reduced. The aim of this study was to clarify the effects of CY dose on tooth extraction socket healing when CY is used with or without bisphosphonate in mice.
Source: Bone - Category: Orthopaedics Authors: Tags: Full Length Article Source Type: research
ConclusionsThese data demonstrate potential use of indatuximab ravtansine in combination with docetaxel or paclitaxel for CD138-positive TNBC.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 11 April 2018 Source:Journal of Fluorine Chemistry Author(s): Larisa Politanskaya, Tatyana Rybalova, Olga Zakharova, Georgy Nevinsky, Evgeny Tretyakov Biologically interesting polyfluorinated 2-aryl-2,3-dihydroquinolin-4-ones (5), 3-benzylidene-2-aryl-2,3-dihydroquinolin-4-ones (6) and 7-methyl-6-aryl-5,6-dihydrodibenzo[b,h]-[1,6] naphthyridines (7) were synthesized using a mild and efficient one-pot procedure starting from 2-aminoacetophenones and trifluorobenzaldehyde in the presence of p-toluenesulfonic acid. Thanks to the use of a high-active polyfluorinated electrophile this synthet...
Source: Journal of Fluorine Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 5 April 2018 Source:Acta Pharmaceutica Sinica B Author(s): Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang, Minhao Wu Chimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR). The CAR-T cell is an effector T cell that recognizes and eliminates specific cancer cells, independent of major histocompatibility complex molecules. The whole procedure of CAR-T cell production is not well understood. The CAR-T cell has been used predominantly in the tr...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
Authors: Yin LL, Wen XM, Lai QH, Li J, Wang XW Abstract Lenalidomide is an immunomodulatory drug and possesses anti-angiogenic and immunomodulatory activities against multiple myeloma. The present study assessed the in vitro effect of lenalidomide combined with cisplatin on MDA-MB-231, a triple-negative breast cancer (TNBC) cell line and explored the underlying molecular mechanism of this combination. Cell viability, apoptosis and the protein expression of phosphorylated (p) and total extracellular signal-regulated kinase (ERK), B-cell lymphoma-2 (Bcl-2), caspase-3, cleaved poly-adenosine diphosphate-ribose polymer...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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