CT scans of Egyptian mummies reveal oldest known cases of breast cancer and multiple myeloma

(University of Granada) An international research team has established that the woman with breast cancer died around 2000 B.C., while the man with multiple myeloma died around 1800 B.C.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Conclusiones: El tratamiento de la OMAM depende del estadio de la enfermedad; la mandibulectomía es un tratamiento efectivo en el estadio 3 y la secuestrectomía en el estadio 2; el estadio 1 suele controlarse con tratamiento conservador.ABSTRACT Introduction: Bisphosphonates are a family of drugs used to inhibit bone resorption. One of their secondary effects is osteonecrosis of the jaws (ONJ). In 2010, scientists began to publish cases of osteonecrosis of the jaws associated with a new drug, denosumab. In 2014 it was recommended to change the name of ONJ to medication-related osteonecrosis of the jaws (MONJ)...
Source: Revista Espanola de Cirugia Oral y Maxilofacial - Category: ENT & OMF Source Type: research
We examined 3,506 unique electronic search citations and 93 full-text papers. We included 17 studies (3 systematic reviews and 14 original studies). Published knowledge syntheses were limited by inclusion of small numbers of studies, with 2 systematic reviews suggesting an increased risk of any SMN and one meta-analysis suggesting a reduced risk of breast SMN after RAI treatment. In a meta-analysis of crude data, the risk ratio of any SMN in RAI-treated TC patients was 0.98 (95% confidence interval, CI, 0.76, 1.27) (n = 10 studies of 65,539 individuals, heterogeneity Q = 64.26, degrees of freedom [df] 9, p
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
One of the most potentially harmful aspects of genetically-modified crops, or GMOs, are that such crops are often engineered to be resistant to specific herbicides or pesticides. A farmer therefore can spray an herbicide to kill weeds, while the GM crop plant survives. But it means that the plant now has herbicide residues in it. Or it may contain its own built-in pesticide such as Bt toxin, expressed by the plant because the gene for this pest-resistant compound has been spliced into the plant’s genetic code. So GMO crops pose a double-whammy: the crop itself with new genetically-programmed components, especially pr...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates dysbiosis Inflammation prebiotic probiotic sibo small intestinal bacterial overgrowth wheat belly Source Type: blogs
Authors: Hernández Pardines F, Serra Verdú MC, Bernal Vidal A, Mayol Belda JM, Mengual Verdú E Abstract The case concerns a 58 year-old female with no medical history of interest who consulted due to binocular diplopia of one week onset. It was associated with costal pain, dyspnoea, intense asthenia and weight loss of 2 months onset. In the blood analysis in the Emergency Department it showed hypercalcaemia, renal failure, and bicytopenia. The chest x-ray showed lytic bone lesions that initially lead to multiple myeloma with extra-osseous involvement. In addition to the corresponding study, in ...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
Conditions:   Cancer (Colon Cancer, Breast Cancer, Lymphoma, Multiple Myeloma);   Elderly;   Antineoplastic Agents;   Cardiotoxicity Interventions:   Other: Intensive cardiovascular monitoring;   Other: No intervention Sponsors:   Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León;   Instituto de Investigación Biomédica de Salamanca;   Instituto de Salud Carlos III Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Cancer is the second leading cause of death worldwide. The primary cause of mortality from cancer is metastasis. While the underlying mechanisms of cancer metastasis are still being unraveled, the gp78 protein involved in ER-associated degradation (ERAD) appears to play a role in metastasis in sarcoma. Targeting gp78 may be a therapeutic option in cancer treatment.The prometastatic activity of ERAD requires the E3 ubiquitin ligase activity of gp78. Gp78 targets the transmembrane metastasis suppressor, KAI1, for degradation. Suppression of gp78 results in the accumulation of KAI1 and a reduced metastatic potency of sarcoma ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Carfilzomib (CFZ) is an irreversible second-generation proteasome inhibitor recently approved for the treatment of relapsed and refractory multiple myeloma. However, its role and molecular mechanism has not been elucidated in human triple negative breast cancer (TNBC). Herein, we investigated antiproliferative and apoptotic effects alone or in combination with Doxorubicin (DOX) on MDA-MB-231 TNBC breast cancer cells.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Scientific forum Source Type: research
AbstractCalvarial lesions are often asymptomatic and are usually discovered incidentally during computed tomography or magnetic resonance imaging of the brain. Calvarial lesions can be benign or malignant. Although the majority of skull lesions are benign, it is important to be familiar with their imaging characteristics and to recognise those with malignant features where more aggressive management is needed. Clinical information such as the age of the patient, as well as the patient ’s history is fundamental in making the correct diagnosis. In this article, we will review the imaging features of both common and unc...
Source: Insights into Imaging - Category: Radiology Source Type: research
We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpitations. An abdominopelvic computed tomography (CT) scan was performed, showing multiple osteolytic lesions distributed in all bone structures and axillary adenopathy on the left side. As part of the approach and given the high suspicion of multiple myeloma, tests were perfor...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
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