The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA

CONCLUSIONSThe PRKD1 E710D hotspot mutation is highly specific for identifying PAC on FNA among cases of ACC and PA, whereas the sensitivity is only modest. Alternative PRKD1 mutations exclude PAC, and are more suggestive of ACC. Cancer Cytopathol 2017. © 2017 American Cancer Society.

Source: Cancer Cytopathology - December 1, 2017 Category: Pathology Authors: Simon Andreasen, Linea Cecilie Melchior, Katalin Kiss, Justin Avery Bishop, Estrid H øgdall, Morten Grauslund, Irene Wessel, Preben Homøe, Tina Klitmøller Agander Tags: Original Article Source Type: research