Prodorsal liposarcoma in a gyr-saker hybrid falcon ( Falco rusticolus x Falco cherrug )

AbstractAn adult female gyr-saker hybrid falcon (Falco rusticolus x Falco cherrug) was brought to our falcon medical and research hospital for evaluation of a rapidly growing mass. Physical and radiographic examination revealed a large, oval-shaped, soft tissue mass on the left prodorsal region. Hematological findings showed moderate leukocytosis and heterophilia while the results of blood biochemical analyses were within normal ranges apart from a moderate elevation of creatine phosphokinase (CPK) activity. A cursory cytological evaluation of fine-needle aspirate of the mass revealed numerous RBCs while neither inflammatory nor neoplastic cells were discernible. Test for acid-fast bacilli in the aspirate was negative. Surgical excision of the mass was performed while the bird was under isoflurane anesthesia. Histopathological examination of biopsy samples of the mass obtained during surgical procedure was consistent with a moderately undifferentiated liposarcoma.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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We present a case of advanced type 1 papillary sarcomatoid renal cell carcinoma infiltrating adjacent organs and showing positivity for MDM2 by immunohistochemistry andMDM2 amplification by fluorescence in situ hybridization. This finding, together with sarcomatoid morphology, poses a potential pitfall for diagnosis with dedifferentiated liposarcoma. MDM2 is known to be altered in various human sarcomas. Only recently, MDM2 alterations have been reported in carcinomas. The presented case illustrates the need of thorough sampling with clinic-pathological correlation before making a final diagnosis in sarcomatoid retroperito...
Source: Virchows Archiv - Category: Pathology Source Type: research
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Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Currently, there is no evidence-based recommendation available regarding the management of lipomas detected during open or laparoscopic inguinal hernia surgery. Due to the extremely low risk of the presence of a liposarcoma routine histologic examination cannot be recommended unless the diameter exceeds 10 cm. PMID: 31690184 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: Applied Immunohistochemistry and Molecular Morphology - Category: Chemistry Tags: Research Articles Source Type: research
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Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
Authors: Seligson ND, Stets CW, Demoret BW, Awasthi A, Grosenbacher N, Shakya R, Hays JL, Chen JL Abstract Dedifferentiated liposarcoma (DDLPS) is a highly morbid mesenchymal tumor characterized and driven by genomic amplification of the MDM2 gene. Direct inhibition of MDM2 has shown promise pre-clinically, but has yet to be validated in clinical trials. Early in vitro studies have demonstrated that pan-histone deacetylase (HDAC) inhibition may have anti-MDM2 effects. Here we present in silico, in vitro, and mouse xenograft studies that suggest that specifically targeting HDAC2 reduces MDM2 expression and has anti-...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
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Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
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