Characterizing Autoimmune Disease-associated Diffuse Large B-cell Lymphoma in a SEER –Medicare Cohort

We used the Surveillance, Epidemiology, and End Results (SEER) –Medicare-linked database to characterize the patterns of presentation, treatment, and survival in older diffuse large B-cell lymphoma (DLBCL) patients with concomitant autoimmune disease. DLBCL patients with autoimmune disease were more likely to be female but otherwise did not differ significant ly from other DLBCL patients in demographic data, treatment, or clinical outcomes.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research

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There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently being diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto ’s thyroiditis. This case is unique as it is one of only a few case reports describing multiple autoimmune conditions in one patient with HL and in this scenario, the thromb...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders, with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto thyroiditis. This case is one of only a few case reports describing multiple autoimmune conditions in a single patient with HL.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Authors: Bozda─č SC, Yüksel MK, Demirer T Abstract Stem cells can be either totipotent, pluripotent, multipotent or unipotent. Totipotent cells have the capability to produce all cell types of the developing organism, including both embryonic and extraembryonic tissues. The Hematopoietic Stem Cells (HSC) are the first defined adult stem cells (ASC) that give rise to all blood cells and immune system. Use of HSCs for treatment of hematologic malignancies, which is also called bone marrow (BM) transplantation or peripheral blood stem cells (PBSC) transplantation is the pioneer of cellular therapy and translation...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusion In the present retrospective claims-based cohort of older patients with DLBCL, concomitant AI disease was uncommon and was more likely to occur in female DLBCL patients, which likely reflects the greater incidence of AI disease in women. The possibility of lower LRS for SLE patients should be explored in future studies. Micro-Abstract We used the Surveillance, Epidemiology, and End Results (SEER)–Medicare-linked database to characterize the patterns of presentation, treatment, and survival in older diffuse large B-cell lymphoma (DLBCL) patients with concomitant autoimmune disease. DLBCL patients with autoi...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conclusions In this retrospective claims-based cohort of older patients with DLBCL, concomitant AI disease was uncommon and was more likely to occur in female DLBCL patients, which likely reflects the higher incidence of AI disease in women. The possibility of lower LRS for SLE patients should be explored in future studies. Teaser We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to characterize patterns of presentation, treatment, and survival in older DLBCL patients with concomitant autoimmune disease. DLBCL patients with autoimmune disease were more likely to be female, but otherwis...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoma frequently associated with monoclonal gammopathy and autoimmune disorders. Therefore, whereas it is well known that the prevalence of autoimmune hemolytic anemia (AIHA) is highest in the more advanced stages of the disease and may depend on the type of treatment administered.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
Publication date: July 2017 Source:Clinical Lymphoma Myeloma and Leukemia, Volume 17, Supplement Author(s): Zaher K. Otrock, Naval Daver, Charles S. Eby Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by excessive activation of the immune system, resulting in overproduction of inflammatory cytokines. Patients usually present with high fever, cytopenias, hyperferritinemia, and hepatosplenomegaly, and their disease process ranges from mild to fatal multiorgan failure. HLH is a heterogeneous group of disorders that can be triggered by infections, neoplasms, or autoimmune diseases. The HLH diagnosis can b...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 July 2017 Source:Clinical Lymphoma Myeloma and Leukemia Author(s): Natalia Kreiniz, Ofrat Beyar Katz, Aaron Polliack, Tamar Tadmor Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world, characterized by the presence of long-lived circulating leukemic cells in the peripheral blood which may infiltrate all organs, particularly those of the reticulo- endothelial system. Liver enlargement and elevation of liver enzymes related to specific involvement by the underlying disease are well-recognized features in these patients. In CLL the differential diagnosis of...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
The chimeric anti-CD20 monoclonal antibody rituximab is widely used for the treatment of B-cell lymphoproliferative disorders as well as for autoimmune diseases. Rituximab induces depletion of the peripheral B cell pool, leading to hypoglobulinemia which results in decreased antibody response to infections. Enteroviral infection can cause life-threatening meningoencephalitis and other systemic chronic syndromes in immune deficient patients
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
Conclusion MDS is rare and tends to be more aggressive in the AYA population. Karyotype was the most important prognostic factor. Allogeneic stem-cell transplantation offered younger patients the best outcomes. Micro-Abstract Little is known regarding myelodysplastic syndromes (MDS) in the younger population. This retrospective review reviewed the characteristics, outcomes, and response to treatment in the adolescent and young adult (AYA) population compared to an older population. MDS was found to be rare and more aggressive in AYA. Karyotype was the most important prognostic factor. Allogeneic stem-cell transplantation o...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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