Immune senescence and biomarkers profile of Bambu í aged population-based cohort.

Immune senescence and biomarkers profile of Bambuí aged population-based cohort. Exp Gerontol. 2017 Dec 13;: Authors: Torres KCL, de Rezende VB, Lima-Silva ML, de Souza Santos LJ, Costa CG, de Melo Mambrini JV, Peixoto SWV, Tarazona-Santos E, Filho OAM, Lima-Costa MF, Teixeira-Carvalho A Abstract During immunosenescence many proinflammatory markers such as cytokines and chemokines are increased. This process called by Franceschi and colleagues as inflammaging is associated with chronic inflammation and the ethiology and pathophysiolgy of many ageing diseases as Alzheimer's and atherosclerosis. The knowledge of immune profile during ageing may provide some interventions that would improve the immune function in elderly and quality of life for old people. However, the identification of a group of potential biomarkers to monitor the ageing process is very difficult. In addition, most of the evidence evaluating immune biomarkers profile is based on data from older Caucasian adults. To our knowledge, no previous Latin American old population-based cohort has evaluated immunological parameters along the ageing process. The present work evaluated CXCL8, CXCL9, CXCL10, CCL2, CCL5, IL-1, IL-6, IL-12, TNF and IL-10 serum levels in 1494 older adults aged 60 to 95 from a population based ageing cohort in Brazil. Our data suggest that there is an increased positive predicted probability of participants to be a high producer of IL-6, CXCL8 and CX...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research