NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice

In conclusion, using transcriptomic profiling in adrenals from three mouse models, we showed that disturbances in adrenal redox homeostasis are mediated not only by under expression of NNT but also by its overexpression. Further, we demonstrated that both under expression or overexpression of NNT reduced corticosterone output implying a central role for it in the control of steroidogenesis. This is likely due to a reduction in the expression of a key steroidogenic enzyme, Cyp11a1, which mirrored the reduction in corticosterone output.

Source: Journal of Endocrinology - December 19, 2017 Category: Endocrinology Authors: Meimaridou, E., Goldsworthy, M., Chortis, V., Fragouli, E., Foster, P. A., Arlt, W., Cox, R., Metherell, L. A. Tags: Research Source Type: research