Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to be used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort

In this study, a new urine-based Tr-DNA molecular assay was evaluated for diagnosis of pulmonary tuberculosis among 428 adult pulmonary TB suspects (164 HIV-positive, 263 HIV-negative) from Cape Town, South Africa. Tr-DNA was isolated from 4 mL EDTA urine, and rapid double-stranded primer-based PCR method performed targeting Mycobacterium tuberculosis–specific direct repeat region.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular Article Source Type: research