A Critical View of “On TB Vaccines, Patients’ Demands, and Modern Printed Media in Times of Biomedical Uncertainties: Buenos Aires, 1920–1950”

AbstractThe putative Pueyo ’s vaccine was a commercial venture that obtained marketing authorization in 1946, a turbulent period of Argentine history. After a few months, health authorities withdrew financial support from the state to buy the vaccine and required patients to sign a written consent to receive that product. A n independent investigation did not find any evidence of benefit in non-clinical and clinical evaluation of the putative vaccine.
Source: Journal of Bioethical Inquiry - Category: Medical Ethics Source Type: research

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Intraperitoneal infection ofMycobacterium tuberculosis from BCG vaccine to male BALB/c mice provoked the formation of multinuclear macrophages in the peritoneal transudate. In 2 and 3 months after infection, their number increased respectively by 34.4 and 66.7% in comparison with intact mice. At all postinfection terms, far greater amounts of caspase 3, p53, Bad, and TNF α were expressed by multinuclear macrophages than by the mononuclear ones. At these terms, the content of Bcl-2-expressing macrophages with different numbers of nuclei was pronouncedly high; of them, the number of multinuclear macrophages was maximum...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
Future Microbiology, Ahead of Print.
Source: Future Microbiology - Category: Microbiology Authors: Source Type: research
CONCLUSION: These results indicate that children born in high TB burden foreign countries should be considered a high-risk group for LTBI in South Korea; the inclusion of these children in LTBI screening should be considered. PMID: 30095331 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
CONCLUSIONS: Two or three H56:IC31 vaccinations at the lowest dose induced durable antigen-specific CD4 T cell responses with acceptable safety and tolerability profiles in M.tb-infected and uninfected adults. Additional studies should validate applicability of vaccine doses and regimens to both QFT-positive and negative individuals. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01865487. PMID: 30092143 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Abstract Tuberculosis (TB) is now among the top ten causes of mortality worldwide being resulted in 1.7 million deaths in 2016. The Bacille Calmette-Guerin (BCG) is the only available TB vaccine which fails to provide consistent protection against pulmonary TB in adults and adolescents despite being efficacious at protecting infants and young children from the most severe, often deadly forms of TB disease. To achieve the goal of global TB elimination by 2050 we will need new interventions including more improved vaccines that are effective in adult individuals who have not been infected with Mycobacterium tubercul...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Authors: Niki M, Yoshiyama T, Miyamoto Y, Okumura M, Niki M, Oinuma KI, Kaneko Y, Matsumoto S, Sasaki Y, Ogata H, Goto H, Kudoh S, Hoshino Y Abstract A novel tuberculosis vaccine to replace BCG has long been desired. However, recent vaccine trials focused on cell-mediated immunity have failed to produce promising results. It is worth noting that most commercially available successful vaccines rely on humoral immunity. To establish a basic understanding of humoral immunity against tuberculosis, we analyzed and evaluated longitudinal levels and avidity of immunoglobulin to various tuberculosis antigens compared with ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Zhidong Hu, Ling Gu, Chun-Ling Li, Tsugumine Shu, Douglas B. Lowrie, Xiao-Yong Fan
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Background: Bacillus Calmette-Guerin (BCG)vaccination is included in the National Regular Schedule(NRS) of Argentina, for newborns immunization. It was launched as part of the NRS to reduce the haematogenous spread of tuberculosis (TB) infections and the development of severe types of TB. BCG-induced systemic infection such as osteoarthritis is an uncommon complication (0.2-2/million dose). Nevertheless, it can occur within the first 6-months post-vaccination even beyond 12-month affecting any bone, usually at a single site, on the metaphysis of long tubular bones.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: UMP. 682 Source Type: research
We present the case of a 26-year-old patient who presented to our hospital in labor. Her medical history included suspected latent tuberculosis diagnosed on a prior chest x-ray and a positive tuberculosis skin test, after which she had undergone treatment with isoniazid. She was unable to recall whether she had received a tuberculosis vaccine as a child when living in Myanmar. Throughout the course of her pregnancy she had persistent microscopic hematuria and proteinuria, of unclear etiology. She was followed in our resident obstetrics clinic, and was evaluated by the nephrology team with plans for a postpartum renal biopsy.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Case report Source Type: research
Authors: Altinoz MA, Ozpinar A, Alturfan EE, Elmaci I Abstract Vinorelbine is a very potent chemotherapeutic agent which is used to treat a number of cancers including breast and non-small cell lung tumors. Vinorelbine mainly acts via blocking microtubules and induces a specific type of cell death called 'mitotic catastrophe/apoptosis' subsequent to mitotic slippage, which is the failure of cells to stay in a mitotic arrested state and replicating their DNA without cytokinesis. Glial tumor cells are especially sensitive to mitotic slippage. In recent years, vinorelbine demonstrated potency in pediatric optic and po...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
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