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A Critical View of “On TB Vaccines, Patients’ Demands, and Modern Printed Media in Times of Biomedical Uncertainties: Buenos Aires, 1920–1950”

AbstractThe putative Pueyo ’s vaccine was a commercial venture that obtained marketing authorization in 1946, a turbulent period of Argentine history. After a few months, health authorities withdrew financial support from the state to buy the vaccine and required patients to sign a written consent to receive that product. A n independent investigation did not find any evidence of benefit in non-clinical and clinical evaluation of the putative vaccine.
Source: Journal of Bioethical Inquiry - Category: Medical Ethics Source Type: research

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(Natural News) An investigation by the British Medical Journal has exposed a horrifying vaccine scam that took place in the same place that many unethical vaccine stories come from – Africa. There, babies were used as guinea pigs to test out a vaccine after the monkeys it was tested on died. According to the report,...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, is currently the only licensed tuberculosis vaccine in use. BCG vaccination is routinely given at birth to billions of children globally,1 including those born in Taiwan since 1981 (Taiwan Centers for Disease Control website: https://goo.gl/4FDNLg). Cutaneous manifestations after BCG inoculation into the dermis may provide an important sign of the host immune response. Here we report a male infant who developed a bacilli-containing granuloma over the vaccination site and subsequent granuloma annulare (GA)-like eruptions over the arm and back.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research
Conclusions: The high mortality in children receiving empirically TB treatment highlights the difficulty in diagnosing childhood TB, the increased likelihood of starting treatment in critically ill children and in children with chronic disease, and the possibility of misdiagnosis. It strengthens the need to invest further in early TB detection and diagnosing nonsevere illness.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
(Oregon Health&Science University) A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans. The new vaccine completely protected 41 percent and reduced overall TB disease by 68 percent in vaccinated rhesus macaques, according to a study published as an Advanced Online Publication of Nature Medicine.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ABSTRACT Tuberculosis (TB) is a serious disease around the world. Bacillus Calmette–Guérin (BCG) is the only TB vaccine licensed for use in human beings, and is effective in protecting infants and children against severe miliary and meningeal TB. However, BCG’s protective efficacy is variable in adults. Novel TB vaccine candidates being developed include whole‐cell vaccines (recombinant BCG (rBCG), attenuated Mycobacterium tuberculosis, killed M. tuberculosis or Mycobacterium vaccae), adjuvanted protein subunit vaccines, viral vector‐delivered subunit vaccines, plasmid DNA vaccines, RNA‐based vacci...
Source: Respirology - Category: Respiratory Medicine Authors: Tags: Invited Review Series: Tuberculosis Updates 2018 Source Type: research
JA Abstract Development of a new vaccine against tuberculosis is urgently needed. Recent work has demonstrated that two related LC3-associated trafficking pathways, autophagy and LC3-associated phagocytosis (LAP), enhance antigen presentation and might play a role in vaccine efficacy. Mycobacterium tuberculosis inhibits both LC3-trafficking pathways. Moreover, the vaccine strain, BCG, induces even less LC3-trafficking than M. tuberculosis, which may help explain its limited efficacy. To determine whether enhanced LC3-trafficking can improve efficacy of a live, attenuated M. tuberculosis vaccine, we took advantage...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusions: The high mortality in children receiving empirically TB treatment highlights the difficulty in diagnosing childhood TB, the increased likelihood of starting treatment in critically ill children and in children with chronic disease, and the possibility of misdiagnosis. It strengthens the need to invest further in early TB detection and diagnosing nonsevere illness.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
(MedPage Today) -- TB vaccine debacle traced to cherry-picked results from preclinical models
Source: MedPage Today Public Health - Category: American Health Source Type: news
An information sheet given to the parents of the babies said the vaccine had been tested on animals and was ‘shown to be safe and effective’. But it did not mention the failed monkey trial.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Marketing | Medical Ethics | Tuberculosis (BCG) Vaccine | Vaccines