Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis

AbstractSTUDY QUESTIONIs serum vitamin D associated with live birth rates in women undergoing ART?SUMMARY ANSWERWomen undergoing ART who are replete in vitamin D have a higher live birth rate than women who are vitamin D deficient or insufficient.WHAT IS KNOWN ALREADYVitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation as well as obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect of vitamin D on conception and early pregnancy outcomes in couples undergoing ART is poorly understood.STUDY DESIGN, SIZE, DURATIONA systematic review and meta-analysis of 11 published cohort studies (including 2700 women) investigating the association between vitamin D and ART outcomes.PARTICIPANTS/MATERIALS, SETTINGS, METHODSLiterature searches were conducted to retrieve studies which reported on the association between vitamin D and ART outcomes. Databases searched included MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and CINAHL. Eleven studies matched the inclusion criteria.MAIN RESULTS AND THE ROLE OF CHANCELive birth was reported in seven of the included studies (including 2026 patients). Live birth was found to be more likely in women replete in vitamin D when compared to women with deficient or insufficient vitamin D status (OR 1.33 [1.08 –1.65]). Five studies (including 1700 patients) found that women replete in vitamin D were more likely to achieve a positive pregnancy test than w...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research