The number of oocytes retrieved during IVF: a balance between efficacy and safety

AbstractSTUDY QUESTIONWhat is the relationship between the number of oocytes collected in fresh IVF treatments and the likelihood of cumulative delivery rate (fresh and frozen) per oocyte aspiration, severe ovarian hyperstimulation syndrome (OHSS) and thromboembolic events?SUMMARY ANSWERCumulative delivery rate per aspiration increases up to 20 oocytes retrieved and then evens out while the incidence of severe OHSS increases more rapidly from around 18 oocytes and thromboembolic events, although rare, occurs in particular if 15 or more oocytes are retrieved.WHAT IS KNOWN ALREADY?Previous studies have shown that the number of oocytes retrieved for IVF is a positive predictor of live birth in fresh cycles. Few studies have investigated cumulative live birth rates and OHSS in relation to the number of aspirated oocytes.STUDY DESIGN, SIZE, DURATIONRetrospective population-based registry study including 39 387 women undergoing 77 956 fresh IVF cycles in the period 2007 –2013 and 36 270 consecutive transfers of frozen/thawed embryos in the period 2007–2014.PARTICIPANTS/MATERIALS, SETTING, METHODSData from The Swedish National Quality Registry of Assisted Reproduction (Q-IVF) including all IVF cycles with oocyte retrieval performed in public or private infertility clinics during the study period, was cross-linked to the National Patient Register regarding diagnostic codes (ICD 10) for severe (OHSS) and thromboembolic events. Oocyte donation cycles were excluded.MAIN RESULTS AND ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research