Frequency of classes I and II HLA alleles in deceased donors of solid organs in Espírito Santo, Brazil

Conclusion: The present study contributed with significant information about the frequency of HLA antigens in deceased donors of solid organs in the Brazilian population that will contribute to optimize t he transplantation process in the country.RESUMO Introdu ção: A população brasileira possui grande mistura racial, tendo sido originada, principalmente, de caucasoides de origem europeia, africanos e índios. As especificidades do sistema de antígenos leucocitários humanos (HLA) variam entre os diferentes grupos populacionais e étnicos, uma vez que demonstram maior similaridade entre populações com origem comum. Objetivo: Determinar a estrutura genética dos alelos HLA de classes I e II em doadores falecidos de órgãos sólidos no Estado do Espírito Santo, Brasil, no período de 2011 a 2015. Métodos: O presente estudo foi realizado em 208 indivíduos falecidos doadores de órgãos sólidos, diagnosticados com morte encefálica, no período de 2011 a 2015, no estado do Espírito Santo, Brasil. A tipificação HLA foi realizada pela técnica de reação em cadeia da polimerase-iniciador específico único (PCR-SSP) utilizando kits para teste de tipagem de ácido desoxirribonucleico (DNA) por SSP genérico de classes I e II, loci A, B e DR. Resultados: O perfil dos doador...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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We report here a huge ADPKD case of kidney transplantation concomitant with simple nephrectomy through thoracoabdominal approach that allows surgeons to manipulate the renal vessels, the adrenal grand, the trigonal ligament, and the lower pole of the kidney under the wide operative field. Because of the direct recognition of the surgical anatomy, it might be safe and feasible for simple nephrectomy in huge ADPKD patients undergoing concomitant kidney transplantation despite of the wide skin incision required by this approach.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionNo conclusion can be drawn on the contribution of somatostatin analogs and immunosuppressant in the occurrence of severe cholecystitis. Prophylactic cholecystectomy is not indicated in patients with this medication.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We describe a technique for osteochondral allograft transplantation to the patella for an isolated patellar chondral lesion (unipolar).
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Authors: Kobbe G, Schroeder T, Rautenberg C, Kaivers J, Gattermann N, Haas R, Germing U Abstract Introduction: Myelodysplastic Syndromes (MDS) are a heterogeneous group of myeloid neoplasms arising in a multipotent hematopoietic stem cell. In about 50% of cases, chromosomal aberrations are detected, which can serve as clonal markers as well as important prognostic factors. In recent years, many somatic mutations have been recognized to be involved in the initiation and clonal evolution of MDS. They provide prognostic information, not only regarding the natural course of disease but also regarding the outcome of all...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Bai H, Wen J, Gong JP, Wu H, Yuan FC, Cao D, Wu YK, Lai X, Wang MH Abstract Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver tissues. The vital role of Notch1/Jagged1 pathway in mouse OLT model has been reported, however, its potential therapeutic mechanism is unknown. Here, we made use of short hairpin RNA-Jagged1 and AAV-Jagged1 to explore the effects of Not...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
In this study, we compared the effect of transplantation of isolated Sca-1+ cells and c-Kit+ cells with that of the crude CDCs (CrCDCs). Focusing on the differences in the ability for secretion of paracrine factors among 3 types of cells, we determined the effects of transplantation of these cells on cardiac intracellular signaling and mitochondrial function in rats with permanently ligated coronary arteries. We showed that the transplantation of these cells resulted in a preservation of the cardiac pump function and mitochondrial respiration at the 8th week after myocardial infarction. However, mitochondrial function in t...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Source: Gastroenterology - Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activity Source Type: research
We present case of a 65-year-old ex-smoker male with history of heart transplantation and EGFR positive metastatic lung adenocarcinoma. At admission he was in a severe clinical condition and treatment with erlotinib was started. Initially he had good clinical and radiologic response to treatment with only grade 1 side effects.  Data about drug interactions between cyclosporine and erlotinib are insufficient but we have to take this interaction into consideration during treatment because both drugs are substrates and inhibitors of CYP34A. In our case erlotinib was safe and well tolerated drug, there were no relevant to...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Publication date: Available online 18 July 2019Source: Cancer CellAuthor(s): Wenjing Su, Hyun Ho Han, Yan Wang, Boyu Zhang, Bing Zhou, Yuanming Cheng, Alekya Rumandla, Sreeharsha Gurrapu, Goutam Chakraborty, Jie Su, Guangli Yang, Xin Liang, Guocan Wang, Neal Rosen, Howard I. Scher, Ouathek Ouerfelli, Filippo G. GiancottiSummaryThe mechanisms that enable immune evasion at metastatic sites are poorly understood. We show that the Polycomb Repressor Complex 1 (PRC1) drives colonization of the bones and visceral organs in double-negative prostate cancer (DNPC). In vivo genetic screening identifies CCL2 as the top prometast...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
This reporter cell line may be used to study the development of mDA neurons or to enrich mDA populations for transplantation.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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