Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers.

Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers. Cancer Invest. 2017 Nov 26;35(10):639-646 Authors: Xiao G, Meng J, Zhang J, Li G, Du N, Qin S, Wang J, Xu C, Ren H, Tang SC, Sun X Abstract To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources. PMID: 29243989 [PubMed - in process]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research