Protein ‐altering variants of PTPN2 in childhood‐onset Type 1A diabetes

ConclusionsThe results provide the first indication that PTPN2 variants contribute to the risk of Type 1A diabetes, independently of known risk SNPs. PTPN2 coding variants possibly induce non‐specific Type 1A diabetes phenotypes in individuals with human leukocyte antigen‐mediated disease susceptibility. Our findings warrant further validation.This article is protected by copyright. All rights reserved.

Source: Diabetic Medicine - December 17, 2017 Category: Endocrinology Authors: M. Okuno, T. Ayabe, I. Yokota, I. Musha, K. Shiga, T. Kikuchi, N. Kikuchi, A. Ohtake, A. Nakamura, K. Nakabayashi, K. Okamura, Y. Momozawa, M. Kubo, J. Suzuki, T. Urakami, T. Kawamura, S. Amemiya, T. Ogata, S. Sugihara, M. Fukami, Tags: Short Report Source Type: research