Organotin(IV) 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioates: Synthesis, characterization and biological activities

Publication date: Available online 14 December 2017 Source:Journal of Organometallic Chemistry Author(s): Farzana Shaheen, Muhammad Sirajuddin, Saqib Ali, Zia-ur-Rehman, Paul J. Dyson, Naseer Ali Shah, Muhammad Nawaz Tahir A series of organotin(IV) derivatives R3SnL (1–3), R2SnLCl (4–6) and R2SnL2 (7–9) (where R = Me, Bu, Ph and L = 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate) were prepared from the reaction of 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate (L-salt) with the corresponding triorganotin(IV) chlorides and diorganotin(IV) dichlorides. All compounds were characterized by FT-IR, 1H, 13C and 119Sn NMR spectroscopy. Dimethylstannyl bis(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioate) (7) was also characterized in the solid state by single crystal x-ray diffraction, showing a distorted octahedral geometry. The diorganotin(IV) derivatives have shown significant antibacterial and antifungal activity and good cytotoxic activity against ovarian cancer cells with IC50 values greater or comparable to that of cisplatin.
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research