Accentuated p53 staining in usual type vulvar dysplasia —A potential diagnostic pitfall

In conclusion, DVIN is difficult to diagnose due to potential histologic overlap with UVIN, especially the warty, or keratinizing, subtype. Accentuated WT p53 in absence of concurrent p16 staining may lead to misdiagnosis of DVIN, especially in small biopsy samples. P16/p53 staining should be performed in tandem with strict adherence to patterns considered positive, as patients with UVIN have significantly less risk of progression.
Source: Pathology Research and Practice - Category: Pathology Source Type: research