The peritoneal macrophages in inflammatory diseases and abdominal cancers.

The peritoneal macrophages in inflammatory diseases and abdominal cancers. Oncol Res. 2017 Dec 13;: Authors: Liu T, Liu F, Peng LW, Chang L, Jiang YM Abstract Peritoneal macrophages (PMs) are the major cell type of peritoneal cells, which participate in multiple aspects of innate and acquired immunity in peritoneal cavity. PMs have an ability to release a large amount of pro-inflammatory and antiinflammatory cytokines, and therefore play a critical role in regulating the differentiation of innate immune cells and inflammatory T cells. Accumulating studies demonstrate that the immunological reactions and inflammatory responses of PMs are strongly related to the pathogenic processes of various inflammatory diseases and abdominal cancers. Consequently, the regulation of PMs activation has gradually emerged as promising target for immunotherapy, and better understanding of the distinctly biological function of PMs in individual diseases is crucial for designing specific and effective therapeutic agents. This review covers the characterization and immunological function of PMs in hosts with inflammatory diseases and abdominal cancers. PMID: 29237519 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research