The role of caveolin-1 in morphine-induced structural plasticity in primary cultured mouse cerebral cortical neurons

In conclusion, morphine was capable of inducing changes in the structural plasticity of primary cultured mouse cortical neurons, and Cav-1 played an important role in this process. Inhibition of Cav-1 expression reduced the morphine-induced increase in the neuronal growth markers GAP-43 and MAP-2. Thus, Cav-1 may be a potential molecular target for inhibiting morphine-induced neuroplasticity.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research