Combined and Isolated Effects of Alcohol Intake and One Night of Sleep Deprivation on Mood States, Hormonal and Inflammatory Responses in Healthy Male Adults: a Crossover Randomized Controlled Trial.

Combined and Isolated Effects of Alcohol Intake and One Night of Sleep Deprivation on Mood States, Hormonal and Inflammatory Responses in Healthy Male Adults: a Crossover Randomized Controlled Trial. Chin J Physiol. 2017 Dec 15;60(6) Authors: Rodrigues R, Franke RA, Teixeira BC, Macedo RCO, Lopes AL, Reischak-Oliveira Á, Baroni BM, Vaz MA Abstract Alcohol intake and sleep deprivation are conditions that cause changes in the physiological status. However, the relationship between biological markers and mood states is not entirely clear yet. The purpose of the study was to compare isolated and combined effects of alcohol intake and sleep deprivation on hormonal and inflammatory responses and in changes in the state of mood. Also, we intended to explain possible changes in mood states through biochemical variations using multiple stepwise regression analysis. Ten healthy male were randomized in four situations: (1) placebo intake + normal sleep (PLA + SLE); (2) alcohol intake + normal sleep (ALC + SLE); (3) placebo intake + sleep deprivation (PLA + SDP); (4) alcohol intake + sleep deprivation (ALC + SDP). While subjects ingested alcohol (1 g/kg of beer), placebo intake was a non-alcoholic beer. The subjects had one night of normal sleep or were subjected to sleep deprivation in the lab for 8 h. After each experimental condition, morning blood samples were taken for assessments of serum levels of glucose, cortisol, testosterone, epineph...
Source: The Chinese Journal of Physiology - Category: Physiology Tags: Chin J Physiol Source Type: research