Zfyve16 regulates the proliferation of B-lymphoid cells

In this study, we generated aZfyve16 knockout mouse strain (Zfyve16KO) and examined its hematopoietic phenotypes and hematopoietic reconstruction ability. The proportion of Tcells in the peripheral blood ofZfyve16KO mice increases compared with that in wild-type mice. This finding is consistent with the role of Zfyve16 in facilitating TGF- β signaling. Unpredictably, B cell proliferation is inhibited inZfyve16KO mice. The proliferation potential ofZfyve16KO B-lymphoid cells also significantly decreasesin vitro. These results suggest that Zfyve16 inhibits the proliferation of T cells, possibly through the TGF- β signaling, but upregulates the proliferation of B-lymphoid cells.

Source: Frontiers of Medicine - December 16, 2017 Category: General Medicine Source Type: research