Magnifying ion mobility spectrometry-mass spectrometry measurements for biomolecular structure studies.

Magnifying ion mobility spectrometry-mass spectrometry measurements for biomolecular structure studies. Curr Opin Chem Biol. 2017 Dec 11;42:101-110 Authors: Majuta SN, Maleki H, Kiani Karanji A, Attanyake K, Loch E, Valentine SJ Abstract Ion mobility spectrometry-mass spectrometry (IMS-MS) provides information about the structures of gas-phase ions in the form of a collision cross section (CCS) with a neutral buffer gas. Indicating relative ion size, a CCS value alone is of limited utility. Although such information can be used to propose different conformer types, finer details of structure are not captured. The increased accessibility of IMS-MS measurements with commercial instrumentation in recent years has ballooned its usage in combination with separate measurements to provide enhanced data from which greater structural inferences can be drawn. This short review presents recent outstanding developments in scientific research that employs complementary measurements that when combined with IMS-MS data are used to characterize the structures of a wide range of compounds. PMID: 29241076 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research