Full genomic analysis of G1P[8] rotavirus strains recovered from rotavirus vaccinated and non ‐vaccinated children hospitalized for acute gastroenteritis in Pune, western India

This study reports the analysis of complete genomes of G1P[8] strains, two each recovered from RotarixTM vaccine recipients and non‐recipients hospitalized for acute gastroenteritis in Pune, western India. All four strains showed a genogroup‐1 backbone with intra‐genotypic diversity in the VP7 and VP4 gene segments and a homogeneous constellation of the internal gene segments. A divergence in the range of 1.4%‐17.3% from RotarixTM vaccine strain was revealed by structural and non‐structural genes of the strains at nucleotide and amino acid level. These data reflect ability of such G1P[8] strains to cause rotavirus infections in humans. This article is protected by copyright. All rights reserved
Source: Journal of Medical Virology - Category: Virology Authors: Tags: Short Communication Source Type: research