Genetic markers a landscape in prostate cancer

Publication date: January–March 2018 Source:Mutation Research/Reviews in Mutation Research, Volume 775 Author(s): J.M. Cozar, I. Robles-Fernandez, L.J. Martinez-Gonzalez, M. Pascual-Geler, Alba Rodriguez-Martinez, M.J. Serrano, J.A. Lorente, M.J. Alvarez-Cubero Prostate cancer (PC) is one of the most common cancers worldwide. The observed variability in progression and responses to the same treatment between patients underlie the genetic heterogeneity of the disease. Nowadays, screening and follow-up biomarkers in PC are still having a deep lack of information, which makes difficult the cancer diagnosis, prognosis and the selection of the most suitable therapies. This is making that currently unnecessary biopsies, over-treatments and hormonoresistances have high rates of prevalence among patients. New biomarkers are urgently needed and in this sense genomic biomarkers could be the most suitable tools. These genetic markers will be helpful for improving the precision of prognostic and the predictive current tools which are employed in the clinical practice. A recent literature search up was conducted, including clinical trials and pre-clinical basic research studies. Keywords included germline variants, prostate cancer, biomarkers, androgen deprivation therapy, screening and liquid biopsy; among others. We have reviewed how germline variants, CNVs and repetitive regions are relevant to prostate carcinogenesis, treatment and progression. Moreover, we have also consi...
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research