Obesity ‐induced mitochondrial dysfunction in porcine adipose tissue‐derived mesenchymal stem cells

Conclusions: Obesity impairs MSC mitochondrial structure and function, possibly mediated partly through miRNA‐induced mitochondrial gene regulation, leading to increased oxidative stress. Importantly, these alterations may limit the therapeutic use of autologous MSCs in subjects with obesity. This article is protected by copyright. All rights reserved

Source: Journal of Cellular Physiology - December 15, 2017 Category: Cytology Authors: Yu Meng, Alfonso Eirin, Xiang ‐Yang Zhu, Hui Tang, Pritha Chanana, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman Tags: ORIGINAL RESEARCH ARTICLE Source Type: research