A more precise approach to fighting cancer

If you are like me, when you get the flu you head straight to the pharmacy and grab the most powerful over-the-counter medicine you can find. But is that really the best approach? After all, your condition, symptoms, and reaction to the virus may be quite different from someone else’s, so why use the same medicine? Instead, you may benefit more from a treatment specifically designed just for you and your ailment. That’s the philosophy behind precision medicine (sometimes referred to as personalized medicine), an approach to cancer prevention and treatment that takes into account a person’s genes, environment, and lifestyle and eliminates the one-size-fits-all concept. “As you get older, you are more likely to battle diseases and ailments, like cancer, and you do not want to waste your time with trial-and-error treatments that may not work and could expose you to various side effects,” says Dr. Paul Avillach, assistant professor of biomedical informatics at Harvard Medical School. “Precision medicine can help take out the guesswork.” The principle behind precision medicine It works like this: doctors rely on family history, lifestyle habits (like diet, exercise, and smoking), and environmental factors (such as where you grew up and where you now live) to determine if you’re more likely to get certain forms of cancer. This can help create preventive strategies like adopting a healthier diet and increasing screenings. If you have a...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Medical Research Source Type: blogs

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Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC03589K, CommunicationLongbing Ling, Haizhou Yu, Muhammad Ismail, Yan-Ping Zhu, Yuan Du, Junhui Qi An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarriers. Results have demonstrated cell membrane-like delivery system possessed an improved cellular uptake... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Morhun JM, Racine NM, Guilcher GMT, Tomfohr-Madsen LM, Schulte FSM Abstract Background: The unique psychosocial needs of parents and caregivers of young children with cancer are poorly understood. The aims of the present study were to examine health-related quality of life (hrqol), stress, and psychological distress in parents of young children (0-4 years) diagnosed with cancer; and the associations between parent psychosocial functioning and child treatment characteristics. Methods: Parents (n = 35) with a child (n = 19 male, 54.3%) 0-48 months of age (median: 31.06 months) on active cancer therapy we...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
TEL AVIV, Israel, June 4, 2020 -- (Healthcare Sales &Marketing Network) -- Alpha Tau Medical, the developer of breakthrough alpha-radiation cancer therapy Alpha DaRT, is pleased to announce the closing of a Series B equity financing of $26 million. Inves... Devices, Oncology, Venture Capital Alpha Tau Medical, alpha-radiation, Alpha DaRT, radiotherapy
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
In this study, the intensity of UVC radiation of the CAP device MiniJet-R (HF Technik, Aachen, Germany) was measured in the range from 220 to 280 nm depending on various device-specific parameters. Depending on the distance to the CAP flame, the UVC intensity reaches values up to 124.5±11 mW m−2. It should be noted here that the UVC radiation generated by the CAP is emitted in all orientations in the room but is also shielded by the geometry of the handpiece of the CAP device. The device-specific settings for the flow rate of the carrier gas, argon, and the power level at the high-frequency (HF) generator of t...
Source: Health Physics - Category: Radiology Tags: Papers Source Type: research
In this study, the intensity of UVC radiation of the CAP device MiniJet-R (HF Technik, Aachen, Germany) was measured in the range from 220 to 280 nm depending on various device-specific parameters. Depending on the distance to the CAP flame, the UVC intensity reaches values up to 124.5±11 mW m. It should be noted here that the UVC radiation generated by the CAP is emitted in all orientations in the room but is also shielded by the geometry of the handpiece of the CAP device. The device-specific settings for the flow rate of the carrier gas, argon, and the power level at the high-frequency (HF) generator of the CAP d...
Source: Health Physics - Category: Physics Authors: Tags: Health Phys Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC03012K, Feature ArticleHyo Sung Jung, Eunbin Hwang In recent years, many inorganic nanoparticle-based chemodynamic therapy (CDT) agents have been employed in cancer therapy; however, the relatively lower catalytic activity compared to that of other CDT agents and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
AbstractPurpose of ReviewEpithelial ovarian cancer is a disease that encompasses a number of histologically and molecularly distinct entities; the most prevalent subtype being high-grade serous (HGS) carcinoma. Standard first-line treatment of advanced HGS carcinoma includes cytoreductive surgery plus intravenous paclitaxel/platinum-based chemotherapy. Despite excellent responses to initial treatment, the majority of patients develop recurrent disease within 3  years. The introduction of the vascular endothelial growth factor (VEGF) inhibitor, bevacizumab, and poly(ADP-ribose) polymerase (PARP) inhibitors into first-l...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response. Upon activation by its main ligand, extracellular ATP, P2X7 can form a nonselective channel for cations to enter the cell. Prolonged activation of P2X7, via high levels of extracellular ATP over an extended time period can lead to the formation of a macropore, leading to depolarization of the plasma membrane and ultimately to cell death. Thus, dependent on its activation state, P2X7 ca...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractTherapeutic intervention for prostate cancer mostly relies on eliminating circulating androgen or antagonizing its effect at the cellular level. As the use of endocrine therapies grows, an under-reported incidence of cardiovascular toxicities occurs in prostate cancer patients. In this review, we summarize data of clinical studies, investigating the cardiovascular and metabolic alterations associated with the use of old and new endocrine drugs (gonadotropin-releasing hormone [GnRH] agonists and antagonists, androgen receptor inhibitors, 17 α-hydroxylase/c-17,20-lyase [CYP17] inhibitor) in prostate cancer. To ...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Industry veteran to lead Medical and Clinical Affairs to advance clinical trials and accelerate further development of cancer therapies WOBURN, Mass., June 3, 2020 -- (Healthcare Sales &Marketing Network) -- Sirtex Medical US Holdings, Inc. ("Sir... Devices, Oncology, Personnel Sirtex Medical, SIR-Spheres, liver cancer, radiotherapy
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
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