A Multigene Signature Based on Cell Cycle Proliferation Improves Prediction of Mortality Within 5 Yr of Radical Nephrectomy for Renal Cell Carcinoma

Conclusions The CCP score is a significant, independent predictor of long-term oncologic outcomes in patients who have undergone nephrectomy for RCC. Combining the molecular classifier with baseline clinical variables allows for accurate, patient-specific risk assessment for use in guiding clinical management. Patient summary In this study, we sought to understand how well gene expression information from individual kidney tumors can predict cancer recurrence and death following surgical removal. We found that the combination of the gene expression test and clinical characteristics provides an accurate prognostic assessment to help inform clinical decisions. A previously established, tissue-based molecular classifier predicted recurrence and mortality after radical nephrectomy, adding prognostic information beyond a validated clinical nomogram. A composite clinical and molecular score was developed, which accurately categorized patients according to their likelihood of mortality.
Source: European Urology - Category: Urology & Nephrology Source Type: research