Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells
Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal metaplasia and gastric adenocarcinoma. Lineage tracing experiments of the gastric corpus in mice have not established whether SPEM derives from proliferating stem cells or differentiated, post-mitotic zymogenic chief cells in the gland base. We investigated whether differentiated cells can give rise to SPEM using a non-genetic approach in mice.
Source: Gastroenterology - Category: Gastroenterology Authors: Megan D. Radyk, Joseph Burclaff, Spencer G. Willet, Jason C. Mills Source Type: research
More News: Adenocarcinoma | Gastric (Stomach) Cancer | Gastritis | Gastroenterology | Genetics | Helicobacter Pylori | Stem Cell Therapy | Stem Cells