Dissociation of Objective and Subjective Daytime Sleepiness and Biomarkers of Systemic Inflammation in Sleep-Disordered Breathing and Systolic Heart Failure

Conclusions:In systolic HF, although overall objective sleepiness was observed, this was not associated with subjective sleepiness (ie, a discordance was identified). Differential upregulation of systemic inflammation in objective sleepiness was observed, findings not observed with subjective sleepiness. These findings suggest that underlying mechanistic pathways of inflammation may provide the explanation for dissonance of objective and subjective sleepiness symptoms in HF, thus potentially informing targeted diagnostic and therapeutic approaches.Commentary:A commentary on this article appears in this issue on page 1369.Citation:Mehra R, Wang L, Andrews N, Tang WH, Young JB, Javaheri S, Foldvary-Schaefer N. Dissociation of objective and subjective daytime sleepiness and biomarkers of systemic inflammation in sleep-disordered breathing and systolic heart failure.J Clin Sleep Med. 2017;13(12):1411–1422.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research