Business Briefing: Lung Transplant Device Receives Federal Approval

The Food and Drug Administration said Tuesday that the Xvivo Perfusion System could lead to more successful transplants of lungs for people with cystic fibrosis and other deadly respiratory diseases.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cystic Fibrosis Respiratory System Food and Drug Administration Source Type: news

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Source: Journal of Sports Sciences - Category: Sports Medicine Authors: Source Type: research
Tiffany Senter (pictured) of Shasta Lake City, California is only 25, but she's been at deaths door twice. Tiffany was born with cystic fibrosis and has had to have two lung transplants.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, we aim to gain insight into innate immune cell dysfunction in CF by investigating alterations in DNA methylation in bronchoalveolar lavage (BAL) cells, composed primarily of lung macrophages of CF subjects compared with healthy controls. All analyses were performed using primary alveolar macrophages from human subjects collected via bronchoalveolar lavage. Epigenome-wide DNA methylation was examined via Illumina MethylationEPIC (850 K) array. Targeted next-generation bisulfite sequencing was used to validate selected differentially methylated CpGs. Methylation-based sample classification was performed using ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Publication date: Available online 15 February 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Giuseppe Fabio Parisi, Anna Portale, Maria Papale, Lucia Tardino, Novella Rotolo, Amelia Licari, Salvatore Leonardi
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Condition:   Cystic Fibrosis in Children Intervention:   Diagnostic Test: spirometry Sponsor:   Gelb, Arthur F., M.D. Recruiting
Source: - Category: Research Source Type: clinical trials
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long-term-expanding human airway organoids from broncho-alveolar resections or lavage material. The pseudostratified airway organoids consist of basal cells, functional multi-ciliated cells, mucus-producing secretory cells, and CC10-secreting club cells. Airway organoids derived from cystic fibrosis (CF) patients allow assessment of CFTR function in an organoid swelling assay. Organoids established from lung cancer resections and metastasis biopsies r...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cancer, Methods & Resources, Molecular Biology of Disease Source Type: research
Background: A correlation between vancomycin (VAN) trough concentrations (VTC) and area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio (AUC/MIC) has not been established in children/adolescents with cystic fibrosis (CF). The primary objective of this study was to determine the correlation between measured VTCs and AUC/MIC using population-based pharmacokinetics. Methods: A retrospective cohort study of children/adolescents diagnosed with CF, 6 to
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
Authors: Malagutti N, Cogliandolo C, Franciosi D, Ferlini A, Rimessi P, Ravani A, Bianchini C, Ciorba A, Stomeo F, Pelucchi S Abstract PMID: 30747503 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Pulmonary disease is the main cause of the morbidity and mortality of patients affected by cystic fibrosis (CF). The lung pathology is dominated by excessive recruitment of neutrophils followed by an exaggerat...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Review Source Type: research
Publication date: 12 February 2019Source: Cell Reports, Volume 26, Issue 7Author(s): Scott R. Tyler, Pavana G. Rotti, Xingshen Sun, Yaling Yi, Weiliang Xie, Michael C. Winter, Miles J. Flamme-Wiese, Budd A. Tucker, Robert F. Mullins, Andrew W. Norris, John F. EngelhardtSummaryToolsets available for in-depth analysis of scRNA-seq datasets by biologists with little informatics experience is limited. Here, we describe an informatics tool (PyMINEr) that fully automates cell type identification, cell type-specific pathway analyses, graph theory-based analysis of gene regulation, and detection of autocrine-paracrine signaling ne...
Source: Cell Reports - Category: Cytology Source Type: research
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