XVIVO Perfusion wins FDA approval for donor lung transport system

Sweden-based XVIVO Perfusion lands FDA Humanitarian Use Device approval for its flagship XPS system for preserving donor lungs. The FDA granted Humanitarian Use Device approval for Sweden-based XVIVO Perfusion for its XPS tissue transport system for preserving donor lungs. XVIVO PerfusionNews Well, Humanitarian Device Exemption (HDE), Food &Drug Administration (FDA), Organ Transplant, Pre-Market Approval (PMA)read more
Source: Mass Device - Category: Medical Equipment Authors: Source Type: news

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Conclusion Our developed orthotopic NSCLC tumours have similarity with biological growth behaviour comparable to that seen in the clinic and could therefore be used as attractive models to study tumour biology and evaluate new therapeutic strategies. The use of human cancer cell lines facilitates testing of different genomic tumour profiles that may affect treatment outcomes. Advances in knowledge The combination of different imaging modalities to identify tumour growth with subsequent use in treatment planning and orthotopic transplantation techniques to develop initially single lesions to ultimate metastases pave the way...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Abstract The field of lung transplant has made significant advances over the past several decades. Despite these advances, morbidity and mortality remain high when compared with other solid organ transplants. As the field moves forward, the speed by which progress can be made will in part be determined by our ability to overcome several stumbling blocks including: donor shortage, proper selection of candidates, primary graft dysfunction, and chronic lung allograft dysfunction. The advances and developments surrounding these factors will have a significant impact on shaping the field within the coming years. In thi...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Authors: Rosso L, Zanella A, Righi I, Barilani M, Lazzari L, Scotti E, Gori F, Mendogni P Abstract Lung transplantation is the only therapeutic option for end-stage pulmonary failure. Nevertheless, the shortage of donor pool available for transplantation does not allow to satisfy the requests, thus the mortality on the waiting list remains high. One of the tools to overcome the donor pool shortage is the use of ex-vivo lung perfusion (EVLP) to preserve, evaluate and recondition selected lung grafts not otherwise suitable for transplantation. EVLP is nowadays a clinical reality and have several destinations of use. ...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Publication date: Available online 20 August 2018Source: Indian Heart JournalAuthor(s): Shayan Marsia, Ariba Khan, Maryam Khan, Saba Ahmed, Javeria Hayat, Abdul Mannan Khan Minhas, Samir Mirza, Nisar Asmi, Jonathon ConstantinAbstractDonors after brain dead (DBD) have been the major source of organ donation due to good perfusion of the organs. However, due to the mismatch in demand and supply of the organ donors and recipients, organ donation after circulatory death has increased recently all over the world. Kidneys, liver and lungs are being used for transplantation from Donors after circulatory death (DCDDs). Recently, he...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
American Journal of Transplantation,Volume 0, Issue ja, -Not available-.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Source Type: research
AbstractPurpose of ReviewThere is a shortage of lungs available to meet the needs of patient who require lung transplantation. Ex vivo lung perfusion (EVLP) has allowed for the assessment and reconditioning of extended criteria and high-risk donor lungs, allowing for an increased volume of lung transplants. Recently, an invested interest in the utilization donation after cardiac death (DCD) donors has surfaced, in which EVLP has played an important role.Recent FindingsClinical studies have shown that EVLP can recondition donor lungs that initially would be unacceptable for transplantation. In a recent study, the interventi...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Transplant International, EarlyView.
Source: Transplant International - Category: Transplant Surgery Authors: Source Type: research
Different mechanical ventilation settings are known to affect lung preservation for lung transplantation. Measurement of particle flow in exhaled air may allow online assessment of the impact of ventilation be...
Source: Intensive Care Medicine Experimental - Category: Surgery Authors: Tags: Research Source Type: research
ConclusionThe next several years will usher in significant changes in understanding and interventions focused on lung injury. This manuscript highlights applications of EVLP to clarify how this system can be used for basic and translational research.
Source: Academic Radiology - Category: Radiology Source Type: research
CONCLUSION: Extubation of patients under ECLS is safe and feasible. Furthermore, in extubated patients, we observed fewer cases of ventilator-associated pneumonia and better 30-day survival rates. PMID: 30044174 [PubMed - as supplied by publisher]
Source: Perfusion - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Perfusion Source Type: research
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