Plant-Made Antibodies: Properties and Therapeutic Applications.

Plant-Made Antibodies: Properties and Therapeutic Applications. Curr Med Chem. 2017 Dec 11;: Authors: Komarova TRV, Sheshukova EV, Dorokhov YL Abstract A cost-effective plant platform for therapeutic monoclonal antibody production is both flexible and scalable. In addition, plant-made antibodies (PMAbs) could be advantageous compared to those produced in animal cells due to the absence of a risk of contamination from nucleic acids or proteins of animal origin. In this review, the various platforms of PMAbs production are described, and the widely used transient expression system based on Agrobacterium-mediated delivery of genetic material into plant cells is discussed in detail. Plants produce less complex and diverse Asn-attached glycans compared to animal cells and contain plant-specific residues. In this review, we examine the features of and approaches to humanizing the Asn297-linked glycan of PMAbs. The prospects for PMAbs in the prevention and treatment of human infectious diseases have been illustrated by promising results with PMAbs against Human immunodeficiency virus, rotavirus infection, Human respiratory syncytial virus, rabies, anthrax and Ebola virus. The pre-clinical and clinical trials of PMAbs against different types of cancer, including lymphoma and breast cancer, are addressed. PMID: 29231134 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research