To progress understanding of disease triggers and modifiers in sarcoidosis, stratification is the key

The vast majority of sarcoidosis literature starts with something similar to the following sentence "Sarcoidosis is a multi-system granulomatous disease of unknown aetiology predominantly affecting the lung". The unknown cause continues to inspire researchers to search for a possible trigger, especially if new and high-throughput methods are at their disposal. The histological hallmark of sarcoidosis is epithelioid cell granuloma. Formation of granuloma is a common reaction towards, for example, bacterial agents. Evidence for bacterial involvement in sarcoidosis consist of presence of bacterial peptides inside lung granuloma and other products derived from sarcoidosis patients, the ability of these products to produce a granulomatous reaction in human and in mice, and the success of anti-microbial therapy in patients [1, 2]. Although active infection has not been found, bacteria, and in particular mycobacteria, are thought to be a causative or disease modifying factor in sarcoidosis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease Editorials Source Type: research

Related Links:

Publication date: Available online 18 May 2019Source: Reumatología Clínica (English Edition)Author(s): Carolina Muñoz, Mauricio Restrepo-Escobar, Manuel Martínez-Muñoz, Andrés Echeverri, Javier Márquez, Luis Fernando PintoAbstractIntroductionSarcoidosis is a complex disease of unknown aetiology, with a variable course and highly different forms of presentation. Our objective was to characterize all our patients with sarcoidosis with emphasis on their clinical presentation and to establish differences between patients with sarcoidosis with and without joint involvement.Method...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Authors: Llabres M, Brito-Zerón P, Ramos-Casals M, Sellares J Abstract INTRODUCTION: Sarcoidosis is a granulomatous systemic disease of unknown cause where the lungs are the most frequently affected. Therapeutic management of the disease is challenging as clinical presentation and prognosis are very heterogeneous. Areas covered: This review summarizes the current knowledge of synthetic therapies for pulmonary sarcoidosis. The most commonly used medication for the treatment of sarcoidosis with lung involvement are glucocorticoids. Nevertheless, not all patients reach an acceptable response or tolerate them an...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Cardiac sarcoidosis is a major cause of death in sarcoidosis patients. In most series, cardiac sarcoidosis is second only to pulmonary sarcoidosis in causes of death related to sarcoidosis [1], although cardiac sarcoidosis has been found to be the leading cause of death in some reports [2,3]. More importantly, the deaths from cardiac sarcoidosis may occur suddenly and early after diagnosis, relating to the development of a small focus of granulomatous inflammation in a strategically vulnerable portion of the cardiac conduction system.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Editorial Source Type: research
Publication date: 14 May 2019Source: Cell Reports, Volume 27, Issue 7Author(s): Jeffrey S. Harding, Melinda Herbath, Yuli Chen, Aditya Rayasam, Anna Ritter, Balazs Csoka, George Hasko, Iacovos P. Michael, Zsuzsanna Fabry, Andras Nagy, Matyas SandorSummaryMany autoimmune and infectious diseases are characterized by the formation of granulomas which are inflammatory lesions that consist of spatially organized immune cells. These sites protect the host and control pathogens like Mycobacterium tuberculosis (Mtb), but are highly inflammatory and cause pathology. Using bacille Calmette-Guerin (BCG) and Mtb infection in mice that...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Gupta N, Chaudhry R, Soneja M, Valappil VE, Malla S, Razik A, Vyas S, Ray A, Khan MA, Kumar U, Wig N Abstract Oligoarticular arthritis (inflammation of upto 4 joints) has a wide range of infectious and non-infectious etiologies. The aim of our study was to identify the features which could help in the differentiation of infectious from non-infectious arthritis. The study was prospective and observational, and included 100 patients with oligoarticular inflammatory arthritis. The final diagnosis was made using standard diagnostic criteria and the patients were categorized into infectious and non-infectious g...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
PMID: 31084397 [PubMed - as supplied by publisher]
Source: Orbit - Category: Opthalmology Authors: Tags: Orbit Source Type: research
It is with great interest that we read the article titled “Clinical epidemiology of familial sarcoidosis: A systematic literature review” by Drs. Terwiel and van Moorsel published recently in Respiratory Medicine [1]. Their systematic review on familial sarcoidosis highlights the great heterogeneity in familial disease prevalence and in familial relati ve risks among published studies. They also emphasize the high heritability (>60%) of sarcoidosis.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Correspondence Source Type: research
This article discusses the main treatments for sarcoid and the specific difficulties of these. It explains to some extent why the frustrations of a condition for which there is no single treatment option have led to the burgeoning of an industry of irrational treatments. The factors that need to be considered before selecting an option for treatment are wider than is the case in most other disease entities as a result of the complexity of the condition, its variable phenotypes, and the individual perceptions and experiences of both veterinarians and owners.
Source: Veterinary Clinics of North America: Equine Practice - Category: Veterinary Research Authors: Source Type: research
Authors: Becker SL, Schlotthauer U, Schäfers HJ, Bals R, Trudzinski FC Abstract The recognition, correct diagnosis and adequate clinical management of infections caused by atypical mycobacteria are challenging tasks in clinical practice. Invasive infections caused by Mycobacterium chimaera, a member of the Mycobacterium avium-intracellulare complex, have been increasingly reported over the past few years. Most infections occurred in patients who had undergone open-chest cardiothoracic surgery. Epidemiological and molecular studies showed that transmission of M. chimaera occurred through intraoperative aerosols...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
CONCLUSION: Literature review suggests possible pathogenesis and the patient's management is discussed. This case highlights the importance of a good systemic history and physical examination, especially with regard to tattoos. PMID: 31072124 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
More News: Respiratory Medicine | Sarcoidosis