To progress understanding of disease triggers and modifiers in sarcoidosis, stratification is the key

The vast majority of sarcoidosis literature starts with something similar to the following sentence "Sarcoidosis is a multi-system granulomatous disease of unknown aetiology predominantly affecting the lung". The unknown cause continues to inspire researchers to search for a possible trigger, especially if new and high-throughput methods are at their disposal. The histological hallmark of sarcoidosis is epithelioid cell granuloma. Formation of granuloma is a common reaction towards, for example, bacterial agents. Evidence for bacterial involvement in sarcoidosis consist of presence of bacterial peptides inside lung granuloma and other products derived from sarcoidosis patients, the ability of these products to produce a granulomatous reaction in human and in mice, and the success of anti-microbial therapy in patients [1, 2]. Although active infection has not been found, bacteria, and in particular mycobacteria, are thought to be a causative or disease modifying factor in sarcoidosis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease Editorials Source Type: research

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Authors: Lee CH, Son JW, Kong EJ PMID: 30238713 [PubMed]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Conclusion: This series reports a higher diagnostic yield than most other published studies and opens platform for direct comparison of each available needle. It also adds to the safety data for this larger needle. In addition, it raises doubt into utility of TBLB for diagnosis of sarcoidosis, which can increase the procedural complications.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Background: The 2016 CHEST consensus guidelines recommend use of either 21- or 22-G needles for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). We decided to prospectively compare sample adequacy and diagnostic yield of the 19-G with the 22-G EBUS needle, hypothesizing that a larger gauge difference might magnify the differences between 2 needle sizes. Methods: Twenty-seven patients undergoing EBUS-TBNA at our institution were evaluated. All cases were performed by a single operator formally trained in interventional pulmonology. Both Olympus 19- and 22-G needles were used at each lymph n...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Authors: Knox A, Black N, Agbaje I Abstract Background: Sarcoidosis is a multisystem inflammatory disease of unknown etiology. It is uncommon, with an incidence of approximately 16.5 per 100,000 men.1 It is characterized by noncaseating epithelioid granulomata that typically affect the chest, skin, eyes, and, much less commonly, the genital system (
Source: Journal of Reproductive Medicine - Category: Reproduction Medicine Tags: J Reprod Med Source Type: research
Conclusions: ROSE was associated with a moderate increase in the accuracy of EBUS-TBNA, but the difference was not statistically significant. The same effect of ROSE was observed in malignant and nonmalignant lesions and this effect was not influenced by the lesion ’s size.Acta Cytologica
Source: Acta Cytologica - Category: Cytology Source Type: research
Clinical Case Reports, EarlyView.
Source: Clinical Case Reports - Category: General Medicine Authors: Source Type: research
We report a case of acute nongranulomatous tubulointerstitial nephritis in an HLA-B27-positive patient with axial spondyloarthritis and Crohn's disease being treated with adalimumab.ResumenLos antagonistas del factor de necrosis tumoral-alfa (ATNF) se utilizan en el tratamiento de múltiples enfermedades, como artritis psoriásica, enfermedad de Crohn, espondilitis anquilosante, artritis idiopática juvenil, generalmente, cuando son refractarias al tratamiento de primera línea.1 La utilización de los ATNF se ha asociado con la inducción de enfermedades autoinmunes, como lupus eritemat...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
To document the clinical presentation, treatment and visual outcome of sarcoid uveitis and to determine the timing and potential risk factors of sarcoidosis progression to symptomatic systemic disease from the time of sarcoid uveitis diagnosis.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
Abstract BACKGROUND: Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis is associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data is available regarding the disease and associated ventricular arrhythmias. METHODS: Data from the National Inpatient Sample (NIS) database 2012-2014, were reviewed. Discharges associated with sarcoidosis were identified as the target population using relevant ICD-9-CM codes. Primary outcome was a diagnosis of ventricular tachycardia (VT) in the sarcoidosis population. Secondary outcomes include rate of ve...
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
AbstractCardiac inflammation/infection imaging with 18F-FDG has been very useful in guiding patient management in conditions such as cardiac sarcoidosis, myocarditis, device infections, and prosthetic implant-related infections. Various protocols have been described to suppress normal myocardial glucose uptake. Certainly, there is need for standardization of protocols but adaptation of protocol to suit individual patient needs is also equally important. In the current article in this issue, Alexandra Cl ément et al have shown that a 7-day ketogenic diet can be used as an alternative method in mice models. This may w...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
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