To progress understanding of disease triggers and modifiers in sarcoidosis, stratification is the key

The vast majority of sarcoidosis literature starts with something similar to the following sentence "Sarcoidosis is a multi-system granulomatous disease of unknown aetiology predominantly affecting the lung". The unknown cause continues to inspire researchers to search for a possible trigger, especially if new and high-throughput methods are at their disposal. The histological hallmark of sarcoidosis is epithelioid cell granuloma. Formation of granuloma is a common reaction towards, for example, bacterial agents. Evidence for bacterial involvement in sarcoidosis consist of presence of bacterial peptides inside lung granuloma and other products derived from sarcoidosis patients, the ability of these products to produce a granulomatous reaction in human and in mice, and the success of anti-microbial therapy in patients [1, 2]. Although active infection has not been found, bacteria, and in particular mycobacteria, are thought to be a causative or disease modifying factor in sarcoidosis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease Editorials Source Type: research

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AbstractClinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis. A prospective study was conducted with two groups of patients: group I (n = 50)—patients with pulmonary sarcoidosis established according to standard criteria; gr...
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
The objective of this review is to assess what is known on the clinical epidemiology of familial sarcoidosis, by combining data from early case reports with recent population based data; aiming to support in clinical decision making and providing information to patients.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Review article Source Type: research
Abstract: Molecular studies have shown more than one species of the genus Paracoccidioides to be the causal agent of paracoccidioidomycosis. Efforts have been made to correlate the identified species with epidemiological and clinical data of patients, aiming to determine the real meaning and impact of new species. Bearing this objective in mind, the authors report a clinical case of paracoccidioidomycosis, from S ão Paulo state, Brazil, that manifested as uncommon sarcoid-like cutaneous lesions and was caused by Paracoccidioides brasiliensis sensu stricto (S1a). The patient was treated with itraconazole 200mg/day fo...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Condition:   Sarcoidosis Intervention:   Other: observation Sponsor:   University of Cincinnati Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: SAPH is associated with a poor prognosis. Proper screening methods may assess whether early identification and treatment improve life expectancy. PMID: 30543925 [PubMed - as supplied by publisher]
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
AbstractCardiac sarcoidosis and amyloidosis have gained recent attention due to substantial advances in imaging and management. In this issue of the Journal of Nuclear Cardiology, imaging experts discuss the role of microvascular perfusion, innervation, targeted imaging of the heart and whole body, and novel molecular targets for imaging inflammation, fibrosis, and amyloidosis. In addition to cutting edge science, experts provide, for the first time, a patient page with information for patients with sarcoidosis and amyloidosis.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Authors: Reguart Oto N, Soler Sendra A, Ortiz Santamaria V PMID: 30502296 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
CONCLUSIONS In a single ophthalmic center in Poland, and throughout Europe, the causes of uveitis are varied. Genetic, geographic, social and environmental factors are likely to affect the cause of uveitis in different populations. PMID: 30504763 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
We present the first case of a 67-year-old man with isolated cutaneous granulomatous reaction involving the trunk, extremities, and face after eighteen months of treatment with ipilimumab for metastatic melanoma. This case documents the eruption of isolated cutaneous granulomatous reaction as a late treatment-related adverse effect of ipilimumab, highlighting the importance of adequate, prolonged follow-up.ResumenLas reacciones granulomatosas «sarcoidosis-like» secundarias a ipilimumab afectarán simultáneamente a múltiples órganos y característicamente se presentarán se...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
This article reviews how the SSTR-directed theranostic concept is currently applied and also reflects on recent developments that hold promise for the future of theranostics in this context.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
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