Medical News Today: Parkinson's: Could this existing drug halt disease progression?
A 50-year-old drug that is commonly used to treat tapeworm infections is found to contain a molecule that can protect against Parkinson's disease.
Conclusion: Physical exercise contributes effectively to the treatment of PD, and can play a preventive and maintenance role of physical fitness and mental health. PMID: 29785199 [PubMed]
Matej Skorvanek, Eva Feketeova, Monica M. Kurtis, Jan Rusz, Karel Sonka
Yonglu Huang, Joshua P. Aronson, Julie G. Pilitsis, Lucy Gee, Jennifer Durphy, Eric Steven Molho, Adolfo Ramirez-Zamora
α-Synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, are thought to be involved in the pathogenesis of Lewy body diseases, such as Parkinson's disease (PD). Although growing evidence suggests that cell-to-cell transmission of α-Syn is associated with the progression of PD and that extracellular α-Syn promotes formation of inclusion bodies, its precise mechanism of action in the extracellular space remains unclear. Here, as indicated by both conventional fractionation techniques and FRET-based protein–protein interaction analysis, we demonstrate that extracellular &al...
Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse modelCorrection to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model, Published online: 25 May 2018; doi:10.1038/s41419-018-0636-4Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model
(MedPage Today) -- Pilot study shows promise for'on'Parkinson's patients
Condition: Parkinson Disease Intervention: Sponsor: University Hospital, Lille Recruiting
A study shows why exposure to some pesticides can raise the risk of Parkinson's disease. Those with a genetic predisposition to the illness may be especially susceptible.
CONCLUSIONS: The prevalence and incidence of dementia increase exponentially from the age of 65 onwards. As a consequence of the progressive ageing of the population and the increase in life expectancy, the number of cases of dementia will rise in the coming decades. Recent studies point to a slight drop in the accumulated risk of dementia adjusted by age groups and sex over the last few decades in some countries. It is possible that by means of primary prevention strategies implemented upon the known risk factors for dementia the burden of dementia on public health will diminish in the future. PMID: 29790571 [PubMed - in process]
Conclusions: Staff training and clinical support in the use of a structured clinical protocol for managing BPSD were linked to reductions in staff job stress, which may in turn increase staff capacity to identify indicators of resident distress and respond accordingly. Site variation in outcomes may relate to organisational and workforce-level barriers that may be unique to the RAC context and should be systematically addressed in future RCT studies of larger PND samples. PMID: 29785228 [PubMed - in process]