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Medical News Today: Parkinson's: Could this existing drug halt disease progression?

A 50-year-old drug that is commonly used to treat tapeworm infections is found to contain a molecule that can protect against Parkinson's disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

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ABSTRACT Rotenone is a common pesticide and has been reported as one of the risk factors for Parkinson disease. Rotenone can cause neuronal death or apoptosis through inducing oxidative injury and inhibiting mitochondrial function. As a natural polyphenolic compound, resveratrol possesses the antioxidant capacity and neuroprotective effect. However, the mechanism underlying the neuroprotective effect of resveratrol against rotenone‐induced neurotoxicity remains elusive. Here, we treated PC12 cells with rotenone to induce neurotoxicity, and the neurotoxic cells were subjected to resveratrol treatment. The CCK8 and LDH act...
Source: The Anatomical Record Part B: The New Anatomist - Category: Anatomy Authors: Tags: Full Length Article Source Type: research
Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors (GHSRs) are present in extrahypothalamic sites in...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Research Source Type: research
Conclusions and Clinical ImportanceThe prognosis for resolution of clinical signs after air embolism is fair, but permanent neurologic deficits or pathologic cardiac arrhythmias can arise. Unpredictable progression warrants close monitoring. Systematic clinic‐based surveillance could provide additional useful information to aid prevention.
Source: Journal of Veterinary Internal Medicine - Category: Veterinary Research Authors: Tags: STANDARD ARTICLE Source Type: research
Excess levels of calcium in the brain might lead to Parkinson's disease, according to new research in Britain.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Researchers from Cambridge University found excessive levels of calcium triggers nerve cell death, despite the mineral being critical for communication in the brain.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Gait impairment is a core feature of Parkinson's disease (PD) with implications for falls risk. Visual cues improve gait in PD but the underlying mechanisms are unclear. Evidence suggests that attention and vision play an important role however the relativ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
BACKGROUND: Gait impairment places older adults and people with Parkinson's disease (PD) at an increased risk of falls when walking over obstacles. Increasing the height of obstacles results in greater challenge to balance however little is known about the...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Falls Source Type: news
This study investigated the contribution o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Falls Source Type: news
Conditions:   Parkinson's Disease;   Tremor Interventions:   Drug: CX-8998;   Drug: Placebo Sponsor:   Cavion, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Calcium may affect how alpha-synuclein — a protein linked to Parkinson's — interacts with structures important for chemical signaling between brain cells.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news
More News: Health | Parkinson's Disease