Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy

Little is known about Alzheimer's disease molecular proteins, beta-amyloid and paired helical filament (PHF) tau, in progressive supranuclear palsy (PSP). Recent techniques have been developed to allow for investigations of these proteins in PSP. We determined the frequency of beta-amyloid deposition in PSP, and whether beta-amyloid deposition in PSP is associated with PHF-tau deposition pattern, or clinical features.

Source: Parkinsonism and Related Disorders - December 13, 2017 Category: Neurology Authors: Jennifer L. Whitwell, J. Eric Ahlskog, Nirubol Tosakulwong, Matthew L. Senjem, Anthony J. Spychalla, Ronald C. Petersen, Clifford R. Jack, Val J. Lowe, Keith A. Josephs Source Type: research