Comparison of Two Naloxone Regimens in Addicted Methadone-Overdosed Patients, a Clinical Trial Study.

CONCLUSION: It seems that gradual titration of naloxone by Tintinalli protocol can reduce major complications compared to the Goldfrank regimen. However, this protocol was not perfect in reducing complications in opioid-dependent methadone-overdosed patients, either. We may need different protocols in opioid-dependent and opioid-naive patients. PMID: 29231146 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29231146?dopt=Abstract

Source: Current Clinical Pharmacology - December 11, 2017 Category: Drugs & Pharmacology Authors: Khosravi N, Zamani N, Hassanian-Moghaddam H, Ostadi A, Rahimi M, Kabir A Tags: Curr Clin Pharmacol Source Type: research