BigH1 -- The key histone for male fertility

(Institute for Research in Biomedicine (IRB Barcelona)) Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility. Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregna...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
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Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
Abstract Infertility represents a major medical, economic, and psychological problem. Stem cells therapy for infertility has a great interest nowadays especially for cancer survivors at pre-reproductive and reproductive age.  Thirty-two adult male albino rats were used, divided equally into four groups; Group I (Control group) received isotonic saline intraperitoneally (i.p.) as vehicle. Group II (Cisplatin-treated group) received Cisplatin (i.p.) at a single dose of 7 mg/kg, and then were sacrificed after 5 days. Group III (Stem-cell-treated group) received Cisplatin (i.p.) at a single dose of 7 mg/kg, ...
Source: Ultrastructural Pathology - Category: Pathology Authors: Tags: Ultrastruct Pathol Source Type: research
Publication date: 5 February 2019Source: Cell Reports, Volume 26, Issue 6Author(s): Abhishek Sohni, Kun Tan, Hye-Won Song, Dana Burow, Dirk G. de Rooij, Louise Laurent, Tung-Chin Hsieh, Raja Rabah, Saher Sue Hammoud, Elena Vicini, Miles F. WilkinsonSummarySpermatogenesis has been intensely studied in rodents but remains poorly understood in humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering analysis of neonatal testes reveals several cell subsets, including cell populations with characteristics of primordial germ cells (PGCs) and spermatogonial stem cells (SSCs). In adult testes, we identi...
Source: Cell Reports - Category: Cytology Source Type: research
(University of California - San Diego) Using a leading-edge technique, UC San Diego School of Medicine researchers defined the cell types in both newborn and adult human testes and identified biomarkers for spermatogonial stem cells, opening a path for new strategies to treat male infertility.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 40 Source Type: research
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Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
Authors: Yu J, Chen B, Zheng B, Qiao C, Chen X, Yan Y, Luan X, Xie B, Liu J, Shen C, He Z, Hu X, Liu M, Li H, Shao Q, Fang J Abstract Germ cell maturation is essential for spermatogenesis and testis homeostasis. ATP synthase serves significant roles in energy storage in germ cell survival and is catalyzed by alterations in the mitochondrial membrane proton concentration. The intrinsic cellular mechanisms governing stem cell maturation remain largely unknown. In the present study, in vivo RNA interference (RNAi) screening of major ATP synthase subunits was performed, and the function of ATP synthase for male fe...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Source: TIME: Science - Category: Science Authors: Tags: Uncategorized fertility Research Source Type: news
Contributors : Abhishek Sohni ; Kun Tan ; Hye-Won Song ; Dana Burow ; Miles F WilkinsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpermatogenesis has been well studied in rodents and invertebrates, but remains poorly understood in humans. As a step towards illuminating human spermatogenesis, we used single-cell RNA-sequencing (scRNAseq) analysis to analyze neonatal and adult human testes. Clustering analysis of neonatal testes revealed 3 germ subsets, including cells with characteristics of primordial germ cells (PGCs), and more differentiated cells with gene expression profiles ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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