BigH1 -- The key histone for male fertility

(Institute for Research in Biomedicine (IRB Barcelona)) Researchers at IRB Barcelona unravel the role of the histone BigH1 in the development of male sex cells from stem cells.The study, which was performed in Drosophila melanogaster, paves the way to a greater understanding of male infertility. Published in Cell Reports, the work sheds light on the mechanisms through which histones regulate how stem cells give rise to differentiated cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract Retinoic acid receptor alpha (RARA), a retinoic acid-dependent transcription factor, is expressed in both somatic and germ cells of the testis. Rara-null male mice with global Rara mutations displayed severely degenerated testis and infertility phenotypes. To elucidate the specific responsibility of germ cell RARA in spermatogenesis, Rara was deleted in germ cells, generating germ cell-specific Rara conditional knockout (Rara cKO) mice. These Rara cKO animals exhibited phenotypes of quantitatively reduced epididymal sperm counts and disorganized germ cell layers in the seminiferous tubules, which worsened...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
Abstract Successful implantation and pregnancy is dependent on sufficient endometrial growth during each reproductive cycle. Here we report the therapeutic effect of either bone marrow-derived cells or the stem cell chemo-attractant CXCL12 on endometrial receptivity in a murine ethanol induced thin endometrium model. Endometrial epithelial area was significantly increased in mice treated with BMDCs, CXCL12 or by co-treatment with both compared with PBS treated controls. Ki-67 and CD31 immunoreactivity was significantly higher in mice treated with either BMDCs, CXCL12 or both. The mRNA expression levels of endometr...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
AbstractAsherman ’s Syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUA) that cause symptoms such as menstrual abnormalities, pelvic pain, infertility, recurrent miscarriage, abnormal placentation and attendant psychological distress. Classically, AS is considered an iatro genic disease triggered by trauma to the pregnant uterus. Different factors can cause the destruction of the endometrium, thus affecting the endometrial stem cell niche and creating IUAs. Curettage of the pregnant uterus appears to be the most common source of this destruction. Nevertheless, some AS cases h...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Infertility, Female;   Endometrium Intervention:   Procedure: UC-MSCs therapy Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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