Assessment of global and local region-based bilateral mammographic feature asymmetry to predict short-term breast cancer risk.

This study aims to develop and test a new imaging marker-based short-term breast cancer risk prediction model. An age-matched dataset of 566 screening mammography cases was used. All "prior" images acquired in the two screening series were negative, while in the "current" screening images, 283 cases were positive for cancer and 283 cases remained negative. For each case, two bilateral cranio-caudal view mammograms acquired from the "prior" negative screenings were selected and processed by a computer-aided image processing scheme, which segmented the entire breast area into 9 strip-based local regions, extracted the element regions using difference of Gaussian filters, and computed both global- and local-based bilateral asymmetrical image features. An initial feature pool included 190 features related to the spatial distribution and structural similarity of grayscale values, as well as of the magnitude and phase responses of multidirectional Gabor filters. Next, a short-term breast cancer risk prediction model based on a generalized linear model (GLM) was built using an embedded stepwise regression analysis method to select features and a leave-one-case-out cross-validation method to predict the likelihood of each woman having image-detectable cancer in the next sequential mammography screening. The area under the receiver operating characteristic curve (AUC) values significantly increased from 0.5863±0.0237 to 0.6870±0.0220 when th...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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Women must be offered lunchtime mammograms or smear tests to halt a collapse in screening rates, a report commissioned by the NHS has stated.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
AbstractBreast cancer (BC) is the most common cancer among females with more than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early stages combined with appropriate treatment is positive, there are still about 30% of patients who will develop locoregional diseases and distant metastases. Molecular imaging is very important in the diagnosis, staging, follow-up, and radiotherapy planning. Additionally, it is useful in characterizing lesions, prognosis, and therapy response in BC patients. Nuclear medicine imaging modalities (SPECT and PET) are of indispensable impor...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
CONCLUSIONS: Mammography and ultrasound remain the leading modalities in breast imaging among males for diagnostic workup of palpable mass, with gynecomastia being the predominant diagnosis. However, presentation with palpable mass was also associated with malignancy. Despite a notable MBC rate in our cohort, the likelihood of cancer is low in young patients and in cases of gynecomastia. PMID: 31599508 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
We examined the hazard function adjusted for adherence to surveillance mammography to examine variations in LR risk and the effect of RT over time.MethodsCrude hazard estimates for the development of LR in a population cohort of DCIS treated by BCS  ± RT were computed. Multivariable extended Cox models and hazard plots were used to examine the association between receipt of RT and risk of each outcome adjusted for baseline covariates and adherence to mammography.ResultsPopulation cohort includes 3262 women treated by BCS; 1635 received RT. Median follow-up was 13  years. LR developed in 364 women ...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Women living in the U.S. but born elsewhere are less likely than women born...Read more on AuntMinnie.comRelated Reading: Cities in New England have highest breast screening rates Should elderly patients continue cancer screening? Mammo rates for immigrant women in U.S. have improved Global lifestyles, immigration patterns bring changes in breast cancer screening Grassroots groups address high breast cancer rate among immigrants
Source: Headlines - Category: Radiology Source Type: news
Williams set out to pay for 53 mammograms, and this Breast Cancer Awareness Month, his foundation announced they far exceeded that goal
Source: Health News: - Category: Consumer Health News Source Type: news
To measure mammography-related pain in two groups of women undergoing regular surveillance as a baseline for future care.
Source: Radiography - Category: Radiology Authors: Source Type: research
Most women know about mammograms and physical exams to check for early signs of breast cancer, but many may not be getting recommended screening exams to help detect and prevent other types of cancer.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Authors: Novikov SN, Chernaya AV, Krzhivitsky PI, Kanaev SV, Krivorotko PV, Artemyeva AS, Popova NS Abstract OBJECTIVE: To compare diagnostic accuracy of scintimammography (SMG) and digital mammography (DS) in the diagnosis of multicentric breast cancer. SUBJECTS AND METHODS: Three hundred and sixty seven women with histologically confirmed breast cancer were included in this analysis. All patients were candidates for conservative breast surgery and had cT1-3N0-1 stage of disease. Scintimammography was performed in prone position 5-10min after intravenous injection of 740MBq of technetium-99m-methoxy-isobtyl-is...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Conclusion: In conclusion, women with breast cancer may attempt to use CAM due to hopelessness. Therefore, in the course of medical treatment of patients, CAM practices should be questioned, they should be provided counseling and if necessary, referred for psychological support.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
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