Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.
Conclusions: Posttransplant MNs have a latency period between that seen in AML/MDS related to alkylators and that associated with topoisomerase II inhibitors. The cytogenetic profile suggests a mutagenic effect on leukemogenesis. The clinical outcome for AML/MDS is dismal, with death occurring at an early phase of treatment. PMID: 29228125 [PubMed - as supplied by publisher]
Nathalie Roders, Florence Herr, Gorbatchev Ambroise, Olivier Thaunat, Alain Portier, Aim é Vazquez, Antoine Durrbach
ConclusionsDosimetry-based therapy with177Lu-DOTA-octreotate is feasible. Patients in whom the absorbed dose to the kidneys reached 23 Gy had a longer OS than those in whom it did not. Patients with CR/PR had a longer OS than those with SD. Bone marrow dosimetry did not predict toxicity.
Every day, three people die while waiting for a transplant. These groups of friends are testimony to the extraordinary healing power of organ donation.
In conclusion, the authors present the first patient with GIST with blistering and skin fragility due to imatinib therapy. As a pathophysiological explanation the authors propose loss of laminin and collagen IV at the DEJ leading to basement membrane instability and blistering. This case also suggests additional features reminiscent of lichen sclerosus induced by imatinib, a drug which is actually known for its antifibrotic effects.
An Afghanistan war veteran who had his genitals blown off by a roadside bomb is the recipient of a donated penis and scrotum that doctors hope will restore his ability to function normally. Doctors said the transplant, made in a 14-hour surgery, is a medical first. The veteran, who asked to remain anonymous for privacy-related […]Related:Source of E. coli-contaminated romaine lettuce still a mystery, FDA saysE. coli outbreak warning expands to all types of romaine lettuceNasal spray of party drug shows promise as fast-acting antidepressant, researchers say
An Afghanistan war veteran who had his genitals blown off by a roadside bomb is the recipient of a donated penis and scrotum that doctors hope will restore his ability to function normally, after a 14-hour surgery that doctors hailed as a medical first. The veteran, who asked to remain anonymous for privacy-related reasons, received […]Related:Source of E. coli-contaminated romaine lettuce still a mystery, FDA saysE. coli outbreak warning expands to all types of romaine lettuceNasal spray of party drug shows promise as fast-acting antidepressant, researchers say
This study is the first to investigate transplanted skin allograft survival using transgenic (Tg) mice with T cell overexpression of Blimp-1. Results Without any immunosuppression, fully MHC-mismatched skin allografts on Tg(+) mice had a significantly prolonged survival rate and partial tolerance at 90 days. Allograft lymphocytic infiltration was decreased in Tg(+) mice and a dampened donor-stimulated alloimmune response was seen. An absolute cell number ratio of inflammatory Th1 and Th17 cells against anti-inflammatory regulatory T (Treg) and IL-10-producing T cells, as well as cytolytic proteins, were significantly decre...
In conclusion, the activities found are closely related to the phenolic composition of these plants.
AbstractPurpose of ReviewPediatric kidney transplants have been performed for more than five decades. To achieve excellent patient outcomes, collaboration of multiple subspecialties is required. This manuscript will review recent advancements in different fields that relate to pediatric kidney transplantation.Recent FindingsWith improvements in patient selection, drugs, perioperative care, surgical technique and postoperative monitoring, outcomes including graft survival, patient survival, and delayed graft function/primary non-function have improved. Immunosuppressive regimens that minimize corticosteroids are increasingl...
Jiaxin Lin, William F. N. Chan, Louis Boon, Colin C. Anderson
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