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Myeloid Neoplasms Following Solid Organ Transplantation: Clinicopathologic Studies of 23 Cases.

Conclusions: Posttransplant MNs have a latency period between that seen in AML/MDS related to alkylators and that associated with topoisomerase II inhibitors. The cytogenetic profile suggests a mutagenic effect on leukemogenesis. The clinical outcome for AML/MDS is dismal, with death occurring at an early phase of treatment. PMID: 29228125 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research

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Contributors : Jun-Ke Zheng ; Yaping ZhangSeries Type : Expression profiling by arrayOrganism : Mus musculusTo tease apart the downstream signaling triggered by the Jam3-mediated signaling, Microarray-sequencing analyses were conducted with WT and Jam3-null LICs.The gene ontology (GO) analysis showed that JAM3 might mainly be involved in signal transduction and phosphorylation pathways. KEGG further indicated that JAM3 was required for the Wnt signaling and hematopoietic cell lineage.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
By JOE FLOWER It’s happening across many parts of the federal government, in many sectors. Officials of the National Park Service have been reprimanded for tweeting about climate change. Scientists at the Centers for Disease Control (CDC) have been warned away from seven specific words in their budget documents, including “fetus,” “evidence-based,” and “transgender.” A HHS employee delivers a list of “potentially objectionable” and/or “problematic” words to a cabinet meeting in December as part of the administration’s comprehensive new “word stra...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
Authors: Zhao RH, Shi Y, Zhao H, Wu W, Sheng JF Abstract INTRODUCTION: Acute-on-chronic liver failure is a common pattern of end-stage liver disease in clinical practice and occurs frequently in patients with chronic hepatitis B or HBV-related cirrhosis. New progress in recent years leads to a better understanding of this disease. Areas covered: This review updates the current comprehensive knowledge about HBV-ACLF from epidemiological studies, experimental studies, and clinical studies and provide new insights into the definition, diagnostic criteria, epidemiology, nature history, pathogenesis, treatment and progn...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Abstract The human solute carrier family 19 member 1 (SLC19A1) is the gene coding for reduced folate carrier 1 (RFC1). In our previous work, we showed that the miR‐595‐related polymorphism, rs1051296 G>T, which was located in the 3’‐untranslated region (3’‐UTR) of SLC19A1, was associated with high methotrexate (MTX) plasma concentrations in pediatric acute lymphoblastic leukaemia (ALL) patients. The present study aimed to investigate the role of miR‐595 in the regulation of SLC19A1 expression and its effects on the cellular uptake and cytotoxicity of MTX in ALL CEM/C1 cells. Luciferase reporter ass...
Source: Basic and Clinical Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research
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Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
This article describes the state of contemporary evidence regarding use of social media tools and interventions to increase access to living donor transplantation, as reported in peer-reviewed medical literature, as well as programs that have not yet been formally evaluated.SummaryAs social media platforms continue to grow and expand, a commitment to understanding and facilitating the use of social media by the transplant community may support patients who are interested in using social media as a tool to find a living kidney donor.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
Artificial intelligence is a popular buzz term in medicine these day. While there’s a lot of simple things pretending to be smart, there are also some pretty impressive AI applications that can be very useful. Thanks to Fast Company, we learned...
Source: Medgadget - Category: Medical Devices Authors: Tags: Emergency Medicine Informatics Source Type: blogs
Purpose: The transition from pediatric to adult medical services is an important time for an adolescent with a renal transplant. Failure to properly transition can lead to medical non-adherence and subsequent loss of graft and/or return to dialysis.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Purpose: Adolescent and young adult (AYA) kidney transplant (KT) recipients experience high rates of premature allograft loss. The healthcare transition (HCT) process is considered contributory. Yet, most AYA with KT navigate transition to adult care successfully, generating a critical need to identify protective factors associated with stable transition. Resilience is a learned and dynamic process with known positive impact on health outcomes. The purpose of this study is to explore the novel role of resilience as a protective factor in securing stable HCT in AYA with KT.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research
Let’s face it. You and I both know most Americans are struggling with their weight. I see it in my practice every day. There’s not one study that will tell you otherwise. What’s more, there’s been an explosion of not only obesity, but of related diseases like diabetes, hypertension and heart disease. But did you realize that the rates of obesity and disease in America began rising at the exact same time the health authorities told us to eat a low-fat diet? It started in 1977 when George McGovern led a Senate Committee that released its “Dietary Goals for the United States.” According to ...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Nutrition clogged arteries fat heart healthy low-fat polyunsaturated fats skinny Weight Loss Source Type: news
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