Postmenopausal Women Should Still Steer Clear of HRT: Task Force

TUESDAY, Dec. 12, 2017 -- Yet again, the nation's leading authority on preventive medicine says postmenopausal women should avoid hormone replacement therapy (HRT). The U.S. Preventive Services Task Force is standing by its original recommendation...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Horm Metab Res 2018; 50: 738-746 DOI: 10.1055/a-0741-8300Bisphosphonates, such as alendronate, have become the most widely used and effective anti-resorptive therapy for postmenopausal osteoporosis. Previous genetic studies suggest that ethnicity may drive differing responses to bisphosphonate therapy in East Asians and non-East Asians. Therefore, the aim of this study was to comparatively evaluate the efficacy of alendronate upon lumbar spinal BMD and vertebral fracture rates in East Asians and non-East Asians with postmenopausal osteoporosis. MEDLINE, EMBASE, and Cochrane CENTRAL were searched for relevant randomized con...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
Abstract17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2 ’s actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attentional performance, as animal studies indicate that supraphysiological doses (i.e., above estrous cycle levels)...
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Publication date: Available online 9 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Craig S. Atwood, Samuel F. EksteinAbstractPrior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE&...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
This study does not support the existence of an important association between plasma concentrations of endogenous testosterone, DHEAS or SHBG with risk of VTE in middle-aged to older men or post-menopausal women not using HRT. PMID: 30296818 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Birgit Alsbjerg, Lise Thomsen, Helle O Elbaek, Rita Laursen, Betina B Povlsen, Thor Haahr, Peter HumaidanAbstract Research question: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen–thawed embryo transfer (HRT–FET) cycles?Design: A cohort study of 244 HRT–FET cycles from a Danish public fertility centre. Data from patients undergoing HRT–FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Conclusion: Cardiovascular risk in Turner syndrome can be reduced using educational approaches to a healthy lifestyle with dietary guidelines. Besides this, we also recommend measuring HoloTC for the prompt detection of B12 defi ciency and to consider hormone replacement therapy in the biochemical assessment of homocysteine in TS.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
ConclusionThis study supports the use of a probably benign assessment of asymptomatic complicated cysts irrespective of age. The sensitivity for malignancy was 100% in our cohort.
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: October 2018Source: Journal of the Academy of Nutrition and Dietetics, Volume 118, Issue 10Author(s): S. Zellers, R. Williams-Hooker, M. Levy, W. Maxey-Trotter
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
AbstractThe Japan Society of Gynecologic Oncology (JSGO) Guidelines 2017 for the Treatment of Uterine Cervical Cancer are for the purpose of providing standard treatment strategies for cervical cancer, indicating treatment methods currently considered appropriate for cervical cancer, minimizing variances in treatment methods among institutions, improving the safety of treatment and prognosis of diseases, reducing the economic and psychosomatic burden of patients by promoting performance of appropriate treatment, and enhancing mutual understanding between patients and healthcare professionals. The guidelines were prepared t...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Mutations in DNA repair pathways, including breast-cancer susceptibility gene 1 (BRCA1) and breast-cancer susceptibility gene 2 (BRCA2) mutation carries, predispose women to an elevated lifetime risk for ovarian cancer (OC) and breast cancer (BC) (National Comprehensive Cancer Network Guidelines, 2018). While the role of bilateral risk-reducing mastectomy is still controversial, risk-reducing salpingo-oophorectomy (RRSO) represents nowadays the main effective prophylactic OC risk measure that should be proposed to BRCA carries, especially once childbearing is complete (National Comprehensive Cancer Network Guidelines, 2018...
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research
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