US FDA approves lung preservation machine

The approval of the XVIVO Perfusion System could lead to more successful transplants of lungs for people with cystic fibrosis and other deadly respiratory diseases.
Source: The Economic Times - Category: Consumer Health News Source Type: news

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Cystic Fibrosis (CF) is a fatal and progressive genetic disorder that affects the lungs and pancreas. It results in persistent lung infections--due to production of thick mucous--which also impair the ability to breathe. I recently spoke with Gunnar Esiason, a CF advocate and patient.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Allergic bronchopulmonary aspergillosis is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus. This disorder is most commonly seen in patients with poorly controlled asthma and cystic fibrosis. It is rarely reported in chronic granulomatous disease patients; however, there are no cases reported with hematopoietic stem cell transplantation in the English literature. Herein, we report a patient with chronic granulomatous disease who had hematopoietic stem cell transplantation and subsequently developed allergic bronchopulmonary aspergillosis.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Conditions:   Cystic Fibrosis;   Innate Immunity;   Inflammatory Response Intervention:   Other: blood and sputum samples Sponsor:   University Hospital, Tours Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Rowbotham NJ, Palser SC, Smith SJ, Smyth AR Abstract INTRODUCTION: Cystic fibrosis is a life-limiting genetic condition characterized by recurrent pulmonary infection. Acquisition of infection can occur from environmental reservoirs, person-to-person transmission and from the healthcare environment. Primary prevention of infections through infection prevention and control measures is an important strategy in cystic fibrosis care. Areas covered: Here we present a systematic review of the evidence base around infection prevention and control in cystic fibrosis. We found 36 studies and 7 guidelines that met o...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
arbara Różalska The justification for the use of herbal supplements with Pulmonaria officinalis L. extract (POE) in the case of staphylococcal lung colonization/infections characteristic for cystic fibrosis (CF), was examined in vitro. The impact of POE phenolic-rich fraction on the virulence attributes of CF-associated Staphylococcus aureus (S. aureus) clinical strains has been assessed, including pathogen adhesion, biofilm formation on native and protein-conditioned surfaces (mucin, elastin), mature biofilm eradication, staphylococcal protein A expression, α-toxin release, and S. a. adhesion to A549...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
HOUSTON– March 19, 2019– The Kidney Cancer Association (KCA) is pleased to announce that Kendall Monroe has joined the organization as its first Chief Advancement Officer (CAO). Monroe brings more than a decade of experience in development, fundraising and donor relations. Monroe most recently worked as the director of planned giving and board management with the University of St. Thomas. She previously held several positions within MD Anderson Cancer Center - including assistant director of development, associate director of development and director of trusts, estates and gift planning. Additional roles i...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
Funding Opportunity RFA-DK-19-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for Cystic Fibrosis (CF) Research and Translation Core Centers. CF Research and Translation Core Centers are designed to support both basic and clinical research on Cystic Fibrosis. CF Research and Translation Core Centers support three primary research-related activities: Research Core services; a Pilot and Feasibility program; and an Administrative Core with an enrichment program. Core Centers provide shared resources to support research to develop and test new therapies for CF ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatenin...
Source: Italian Journal of Pediatrics - Category: Pediatrics Authors: Tags: Commentary Source Type: research
Cystic fibrosis (CF; OMIM #219700) is a common autosomal recessive disease caused by pathogenic variants (henceforward mutations) in the cystic fibrosis transmembrane conductance regulator gene (CFTR). The spectr...
Source: BMC Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
AbstractFamilial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatening disease in the Caucasian population. A recent study indicates that the gluten/gliadin-derived peptide (P31 –43) can cause CFTR inhibition in intestinal epithelial cells, thus causing a local stress response that contributes to the immunopathology of celiac disease (CD). Accordingly, an increased prevalence of CD has been observed in several cohorts of CF patients. CD is characterized by a permanent int...
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
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