Detection of valvular heart diseases using impedance cardiography ICG

Publication date: Available online 11 December 2017 Source:Biocybernetics and Biomedical Engineering Author(s): Souhir Chabchoub, Sofienne Mansouri, Ridha Ben Salah Impedance cardiography (ICG) is a simple, non invasive and cost effective tool for estimating stroke volume, cardiac output and other hemodynamic parameters. It has been successfully used to diagnose several cardiovascular diseases, like the heart failure and myocardial infarction. In particular, valvular heart disease (VHD) is characterized by the affection of one or more heart valves: mitral, aortic, tricuspid or pulmonary valves and it is usually diagnosed using the Doppler echocardiography. However, this technique is rather expensive, requires qualified expertise, discontinuous, and often not necessary to make just a simple diagnosis. In this paper, a new computer aided diagnosis system is proposed to detect VHD using the ICG signals. Six types of ICG heartbeats are analyzed and classified: normal heartbeats (N), mitral insufficiency heartbeats (MI), aortic insufficiency heartbeats (AI), mitral stenosis heartbeats (MS), aortic stenosis heartbeats (AS), and pulmonary stenosis heartbeats (PS). The proposed methodology is validated on 120 ICG recordings. Firstly, ICG signal is denoised using the Daubechies wavelet family with order eight (db8). Then, these signals are segmented into several heartbeats and, later, subjected to the Linear Prediction method (LP) and Discrete Wavelet Transform approach (DWT) to extr...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research

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Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Ashley McDonough ; Richard V Lee ; Shahani Noor ; Chungeun Lee ; Thu Le ; Michael Iorga ; Jessica L Phillips ; Sean Murphy ; Thomas M öller ; Jonathan R WeinsteinSeries Type : Expression profiling by arrayOrganism : Mus musculusStroke is the fifth leading cause of death in the United States and is a leading cause of serious long-term disability worldwide. Innate immune responses are critical in stroke pathophysiology, and microglia are key cellular effectors in the CNS response to ischemia/reperfusion. Using a transcriptional analysis approach, we identified a robust interferon (IFN)-stimulated gene res...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Contributors : Bing Han ; Honghong YaoSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Mus musculusAstrocyte activation is involved in the context of stroke. Our study provides a potential new therapeutic strategy to astrocyte activation in the context of stroke.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Mus musculus Source Type: research
Ventricular assist devices (VADs) have improved wait list survival in children with end-stage heart failure. However, questions remain about the optimal timing of VAD implantation. In this cost-effectiveness analysis, we compared immediate intracorporeal continuous VAD implantation to a watchful waiting approach using continuous inotropic therapy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (190) Source Type: research
The initial project of ACTION (Advanced Cardiac Therapies Improving Outcomes Network) is focused on improving stroke rates in patients implanted with a ventricular assist devices (VAD) in participating centers. The initial interventions targeted improving communication, anticoagulation, and blood pressure management. We sought to describe the characteristics and outcomes of patients implanted with intracorporeal, continuous flow VADs (cfVAD).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (184) Source Type: research
PIONEER-HF established the safety of the angiotensin receptor-neprilysin inhibitor (ARNI), sacubitril-valsartan (S/V), in patients hospitalized with acute decompensated heart failure after achieving hemodynamic stability. We have previously shown that transitioning patients in cardiogenic shock directly from intravenous (IV) vasoactive (i.e. vasodilators or inotropes) drugs to S/V can be done safely with tolerance to one-month follow-up. Here we further characterize the hemodynamic impact of S/V after patients have been optimized on vasoactive therapy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (111) Source Type: research
Cardiac power index (CPI) has been used as a predictor of outcomes in cardiogenic shock. Cardiac power efficiency (CPE), which is the CPI divided by the PCWP, has been used successfully to predict response to a durable counterpulsation MCS device. The aim of this study is to evaluate the utility of CPE in predicting outcomes in advanced heart failure patients presenting with decompensation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (109) Source Type: research
Paradigm HF trial showed that Sacubitril/Valsartan (LCZ696) 97/103 mg bid reduces the risk of death and hospitalizations for heart failure (HF). We tested the hypothesis that this clinical benefit is reflected by changes in hemodynamic profile in a population of patients (pts) affected by advanced HF.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (108) Source Type: research
This study will assess potential benefits to patients who have advanced heart failure and require additional circulatory support.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (107) Source Type: research
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