Teaching an Old Scaffold New Recognition Tricks: Oligopyrrolamide Antagonists of IAPP Aggregation

Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02910A, PaperSunil Kumar, Maria C Vogel, Andrew D Hamilton A library of N-substituted oligopyrrolamides was designed to modulate the aggregation kinetics of islet amyloid polypeptide (IAPP). IAPP is a hormonal peptide, co-secreted with insulin in the pancreatic [small beta]-cells. IAPP... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research