fMRI, PET could help foresee epileptic seizure issues

Researchers have developed a method to integrate functional MR (fMRI) and PET...Read more on AuntMinnie.comRelated Reading: PET/MRI outclasses MRI alone for pelvic cancer recurrence fMRI helps guide therapy designed to reduce tinnitus Researchers resolve PET/MRI issue for epilepsy patients PET/MRI could help diagnose kidney transplant infection
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Authors: Campello E, Spiezia L, Adamo A, Simioni P Abstract INTRODUCTION: Fifty-three years after the first description of an inherited prothrombotic condition (antithrombin deficiency), our knowledge on hereditary and acquired causes of hypercoagulability that can predispose carriers to venous thromboembolism (VTE) has greatly improved. Areas covered: Main causes of hereditary thrombophilia are summarized alongside new prothrombotic mutations recently discovered. The main causes of acquired thrombophilia, and namely, antiphospholipid antibody syndrome and hyperhomocysteinemia, are also discussed together with othe...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
obo-Castañón MJ Abstract Cancer diagnosis based on serum biomarkers requires receptors of extreme sensitivity and selectivity. Tunability of aptamer selection makes them ideal for that challenge. However, aptamer characterization is a time-consuming task, not always thoroughly addressed, leading to suboptimal aptamer performance. In this work, we report on the affinity characterization and potential usage of two aptamers against a candidate cancer biomarker, the neutrophil gelatinase-associated lipocalin (NGAL). Electrochemical sandwich assays on Au electrodes and SPR experiments showed a restricted ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Adenosine is closely related to the development of cancer, and it can be regarded as a biomarker for cancer diagnosis and therapy. Here, a T7 exonuclease (T7 Exo)-assisted and target-triggered cascade dual recycling signal amplification strategy was developed for the sensitive and specific detection of adenosine. In this strategy, a capture strand (Cap)-inhibit strand (Inh) duplex and a DNA hairpin with intact G-quadruplex sequence are designed. In the presence of adenosine, Cap binds with adenosine specifically to form Cap-adenosine complex with recessed 5'-hydroxyl termini, causing the release of Inh. U...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Anterior gradient protein 2 homolog (AGR) is a potential tumor biomarker and plays an important role in tissue development and regeneration. The intracellular detection of AGR is rarely reported. By conjugating the AGR aptamer with a cytosine base sequence as Ag cluster template, a highly fluorescent probe (MA@AgNCs) was synthesized for targeting intracellular AGR. The MA@AgNCs display a maximum fluorescence peak at 565 nm, and possess an excellent quantum yield (QY = 87.43%), small size, great biocompatibility, low toxicity, and good stability. Moreover, the as synthesized MA@AgNCs show high specific...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
In this study, a novel approach for preparing fluorescent boronic-acid-modified carbon dots (C-dots) for the detection of SA was developed. The functionalized C-dots were synthesized by a facile, one-step hydrothermal method using 3-pyridineboronic acid as the sole carbon source. The added SA selectively recognized the C-dots, leading to the fluorescence quenching of the C-dots in a linear range of 80-4000 μM with a detection limit of 54 μM. The as-developed boronic-acid nanoprobe was successfully applied for the detection of SA in human serum samples with satisfactory results. In addition, this method afforded r...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Peroxynitrite (ONOO-) is an important reactive oxygen species (ROS), which can react with a variety of biologically active species and cause many diseases, such as cancer, neurodegenerative disorders. Herein, we develop a novel far-red fluorescent probe DCM-KA, which is equipping with α-ketoamide moiety caged DCM-NH2. The probe exhibits fluorescence off-on response to ONOO- over other biological interfering analytes by ONOO--induced α-ketoamide deprotection reaction. More importantly, the probe is biocompatible and has been successfully utilized to visualize endogenous ONOO- production in macr...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Zhen Xiang, Shuzheng Song, Zhenggang Zhu, Wenhong Sun, Jaron E. Gifts, Sam Sun, Qiushi Shauna Li, Yingyan Yu, Keqin Kathy Li
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Juanying Xie, Ran Liu, Joseph Luttrell, Chaoyang Zhang
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Merck&Co Inc said on Tuesday its cancer drug Keytruda failed the main goals of a late-stage trial and did not extend life of patients with a type of liver cancer.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
ST. LOUIS - A Colorado cancer victim on Feb. 11 sued Monsanto Co. in Missouri federal court, alleging that it committed "scientific fraud" and "colluded" with the Environmental Protection Agency in promoting as safe the herbicide Roundup, which contains that active ingredient glyphosate. The attorneys representing the man have filed identical complaints on behalf of multiple plaintiffs (Steven Burchfield v. Monsanto Co., No. 19-205, E.D. Mo.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news
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