miR-223 is repressed and correlates with inferior clinical features in mantle cell lymphoma through targeting SOX11

MicroRNAs (miRs) are a class of noncoding single-stranded RNA molecules of 21 –23 nucleotides, which bind to 3′-untranslated region (UTR) of the target messenger RNA (mRNA) and trigger either mRNA degradation or inhibition of translation depending on the degree of complementarity between miR and its target [1]. Since the first description of the loss of miR-15/16 in chron ic lymphocytic leukemia (CLL) [2], studies have reported the deregulation of miRs in a variety of hematopoietic and solid tumors, functioning as either oncogenes or tumor suppressors regarding context and cell types [3–5].

Source: Experimental Hematology - November 20, 2017 Category: Hematology Authors: Keshu Zhou, Xiaoyan Feng, Yanying Wang, Yanyan Liu, Long Tian, Wenli Zuo, Shuhua Yi, Xudong Wei, Yongping Song, Lugui Qiu Tags: Review Source Type: research