Use of carbon-11 labelled tool compounds in support of drug development

Publication date: November 2017 Source:Drug Discovery Today: Technologies, Volume 25 Author(s): Giulia Boscutti, Mickael Huiban, Jan Passchier The pharmaceutical industry is facing key challenges to improve return on R&D investment. Positron emission tomography (PET), by itself or in combination with complementary technologies such as magnetic resonance imaging (MRI), provides a unique opportunity to confirm a candidate’s ability to meet the so-called ‘three pillars’ of drug development. Positive confirmation provides confidence for go/no-go decision making at an early stage of the development process and enables informed clinical progression. Whereas fluorine-18 has probably gained wider use in the community, there are benefits to using carbon-11 given the greater flexibility the use of this isotope permits in adaptive clinical study design. This review explores the scope of available carbon-11 chemistries and provides clinical examples to highlight its value in PET studies in support of drug development.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research