Glut3 Addiction: A Druggable Vulnerability in Glioblastoma

Publication date: 11 December 2017 Source:Cancer Cell, Volume 32, Issue 6 Author(s): Severa Bunda, Gelareh Zadeh, Kenneth D. Aldape The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM. Teaser The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggable vulnerability in a subpopulation of GBM.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research