Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage

Conclusions:
Our data suggest that moderate hyperinsulinemia in response to insulin resistance or lowering of TNF-α levels within the aorta attenuates vascular damage, this protective effect being mediated by UCP-2 expression levels through iNOS.

Source: Cardiovascular Diabetology - July 31, 2014 Category: Cardiology Authors: Almudena Gómez-HernándezLiliana PerdomoNatalia de las HerasNuria BeneitÓscar EscribanoYolanda OteroCarlos GuillénSabela Díaz-CastroverdeBeatriz Gozalbo-LópezVictoria CachofeiroVicente LaheraManuel Benito Source Type: research