A common humoral background of intraocular and arterial blood pressure dysregulation?

A common humoral background of intraocular and arterial blood pressure dysregulation? Curr Med Res Opin. 2017 Dec 08;:1-19 Authors: Skrzypecki J, Grabska-Liberek I, Przybek J, Ufnal M Abstract It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. We hypothesize that in some hypertensive patients, disturbances in intraocular pressure regulation may depend on biological effects of blood borne hormones underlying a particular type of hypertension, rather than on blood pressure level itself. This review compares the effects of hormones on blood pressure and intraocular pressure, in order to identify a hormonal profile of hypertensive patients with an increased risk of intraocular pressure surge. We searched PUBMED database to identify preclinical and clinical studies investigating role of angiotensin II, vasopressin, adrenaline, noradrenaline, prostaglandins and gaseous transmitters in the regulation of blood pressure and intraocular pressure. Studies included in the review suggest that intraocular and blood pressures often follow a different pattern of response to the same hormone. For example, vasopressin increases blood pressure, but decreases intraocular pressure. In contrast, high level of nitric oxide decreases blood pressure, but increases intraocular pre...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research