Non-invasive peripheral nerve stimulation via focused ultrasound in vivo .

Non-invasive peripheral nerve stimulation via focused ultrasound in vivo. Phys Med Biol. 2017 Dec 07;: Authors: Downs ME, Lee SA, Yang G, Kim S, Wang Q, Konofagou EE Abstract Focused ultrasound (FUS) has been employed on a wide range of clinical applications to safely and non-invasively achieve desired effects that have previously required invasive and lengthy procedures with conventional methods. Conventional electrical neuromodulation therapies that are applied to the peripheral nervous system (PNS) are invasive and/or non-specific. Recently, focused ultrasound has demonstrated the ability to modulate the central nervous system and ex vivo peripheral neurons. Here, for the first time, noninvasive stimulation of the sciatic nerve eliciting a physiological response in vivo is demonstrated with FUS. FUS was applied on the sciatic nerve in mice with simultaneous electromyography (EMG) on the tibialis anterior muscle. EMG signals were detected during or directly after ultrasound stimulation along with observable muscle contraction of the hind limb. Transecting the sciatic nerve downstream of FUS stimulation eliminated EMG activity during FUS stimulation. Peak-to-peak EMG response amplitudes and latency were found to be comparable to conventional electrical stimulation methods. Histology along with behavioral and thermal testing did not indicate damage to the nerve or surrounding regions. The findings presented herein demonstrate that FUS can serve as a targ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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Publication date: Available online 14 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): A Sureshkumar, B Hansen, D ErsahinAbstractNuclear medicine (NM) plays a unique role in the detection of infection and inflammation. This review looks at different methods that are used for detection of infections and explains how they differ from cross sectional imaging such as CT and MRI. Images are provided to aid understanding and interpretation of NM scans. There is also a brief discussion of future techniques that can alter the use of NM for infection work up.
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 14 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): D. Hynes, P. Aghajafari, B. Janne d'OthéeInterventional Radiology (IR) is plays a crucial role in the management of localized infections, utilizing percutaneous access to loculated fluid collections for drainage and source control. Interventions have been developed in multiple organs and systems and used over decades, allowing the IR physician to provide patient care in many cases where surgical options are not optimal. In this review, we will examine the emergent, urgent and routine nature of various IR procedures...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 14 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): C. Duffin, S. Mirpour, T. Catanzano, C. MooreAbstractAlthough radiologic imaging of bowel infections is often a precursor to definitive diagnosis by endoscopy, biopsy, or stool cultures, imaging can provide critical information for diagnosis and management. Many infectious entities such as viral, bacterial, and parasitic infections can be discovered on imaging. Furthermore, imaging characterizes the extent of infection, involvement of specific bowel segments, and presence of complications in the abdomen. Utilizing a multi...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Objectives The aim of this study was to investigate ultrasound time-harmonic elastography for quantifying aortic stiffness in vivo in the context of aging and arterial hypertension. Materials and Methods Seventy-four participants (50 healthy participants and 24 participants with long-standing hypertension) were prospectively included between January 2018 and October 2018, and underwent ultrasound time-harmonic elastography of the upper abdominal aorta. Compound maps of shear-wave speed (SWS) as a surrogate of tissue stiffness were generated from multifrequency wave fields covering the full field-of-view of B-mode ultr...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
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Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionUsing transvaginal NOTES by applying the method of single-incision laparoscopic surgery via the vaginal route, adnexal surgery and hysterectomy could be performed safely and effectively in selected patients
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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