Innovations in Functional Neurosurgery and Anesthetic Implications
Functional neurosurgery has undergone rapid growth over the last few years fueled by advances in imaging technology and novel treatment modalities. These advances have led to new surgical treatments using minimally invasive and precise techniques for conditions such as Parkinson’s disease, essential tremor, epilepsy, and psychiatric disorders. Understanding the goals and technological issues of these procedures is imperative for the anesthesiologist to ensure safe management of patients presenting for functional neurosurgical procedures. In this review, we discuss the advances in neurosurgical techniques for deep brain stimulation, focused ultrasound and minimally invasive laser-based treatment of refractory epilepsy and provide a guideline for anesthesiologists caring for patients undergoing these procedures.
We describe some of the neurological cases portrayed in Mann's work, and particularly epilepsy described in The Buddenbrooks, Felix Krull and The Magic Mountain, meningitis, neurosyphilis and migraines depicted in Doctor Faustus, and essential tremor described in The Magic Mountain and Doctor Faustus. We conclude with reflections about Mann's interest in diseases and particularly in neurology. PMID: 30336458 [PubMed - in process]
Publication date: Available online 19 October 2018Source: Neurología (English Edition)Author(s): P. Cifuentes-Canorea, I. Camacho-Bosca, L. Perucho-González, E. Santos-Bueso
In conclusion, our results have demonstrated that the pairing strategy potentiated the detection of an altered brain state prior to the seizure onset. The EEG probing enhancement method opens many possibilities for both diagnosis and treatment of epilepsy.
Publication date: Available online 19 October 2018Source: Epilepsy &BehaviorAuthor(s): Kamil Detyniecki, Jane O'Bryan, Tenzin Choezom, Grzegorz Rak, Chanthia Ma, Shiliang Zhang, Jennifer Bonito, Lawrence J. HirschAbstractObjectiveThe purpose of this prospective observational study was to describe the prevalence and adverse outcomes associated with seizure clusters (defined as ≥ 2 seizures in a 6-hour period) in a large sample of adult patients with a range of epilepsy severities and to identify clinical characteristics predictive of clustering.MethodsPatients maintained a seizure diary and were contacted monthl...
Publication date: Available online 19 October 2018Source: Epilepsy &BehaviorAuthor(s): Mariusz S. Wiglusz, Wiesław J. Cubała, Adam Włodarczyk
ConclusionsChildren with epilepsy demonstrate poor physical literacy levels, with potential immediate and long-lasting negative impacts on general health and psychosocial well-being. Programs promoting physical literacy in children with epilepsy should be encouraged, specifically interventions decreasing screen time and enhancing muscular endurance and motor skills, thereby facilitating healthier lifestyles.
Reply to "Mitochondrial tRNA Glutamic Acid Variant 14709T>C Manifesting as Myoclonic Epilepsy with Ragged Red Fibers". Chin Med J (Engl). 2018 Oct 20;131(20):2519-2520 Authors: Ban R, Guo JH, Pu CQ, Shi Q, Liu HX, Zhang YT Abstract PMID: 30334547 [PubMed - in process]
Mitochondrial tRNA Glutamic Acid Variant 14709T>C Manifesting as Myoclonic Epilepsy with Ragged Red Fibers. Chin Med J (Engl). 2018 Oct 20;131(20):2518-2519 Authors: Finsterer J, Scorza FA, Fiorini AC, Scorza CA, de Almeida AC Abstract PMID: 30334546 [PubMed - in process]
In this study, the antimyoclonic effects of monotherapies, including levetiracetam (LEV), clonazepam (CZP), valproic acid (VPA), and topiramate (TPM) compared to combination therapy group with LEV and CZP on MERRF, were evaluated to find a more advantageous approach on the treatment of myoclonic seizures. Methods: Treatments of myoclonic seizures with VPA, LEV, CZP, and TPM were reported as monotherapies in 17 MERRF patients from Qilu Hospital between 2003 and 2016, who were diagnosed through clinical data and genetic testing. After 1-4 months of follow-up (mean: 82.9 ± 28.1 days), 12 patients that exhibited po...
AbstractMesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30 years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt. Thirty healthy children and young adults, age- and sex-matched to the patients, were included...