Effect of melatonin on cytokine levels in a hyperthermia-induced febrile seizure model.
In this study, we investigated serum cytokine levels in a hyperthermia-induced febrile rat seizure model and the effect of melatonin. A total of 28 male Sprague-Dawley rats were divided into four groups: the control (C) group, healthy melatonin (MT) group, and hyperthermia-induced febrile seizure groups with (HIFS-MT) and without (HIFS) administration of melatonin. Melatonin (80 mg/kg) was given intraperitoneally 15 min before the seizure. HIFS was induced by placing the rats in 45°C water. The rats were sacrificed under anesthesia after the seizure. Blood samples were drawn by transcardiac puncture to measure serum cytokine and melatonin levels. Serum interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α levels were lower in the HIFS group than those in the C group (p = 0.005, p = 0.200, p = 0.011, and p = 0.016, respectively). All serum cytokine levels of rats in the MT and HIFS-MT groups were similar to those in the C group. This experimental rat model demonstrated that serum cytokine levels decrease with HIFS and that administering melatonin maintains serum cytokine levels. These results suggest that cytokines may play role in the anticonvulsive activity of melatonin in rats with febrile seizures. PMID: 29208169 [PubMed - in process]
This study aimed to evaluate the effect of poly(dimethylsiloxane) on the mechanical properties of chitosan-alginate (CA) polyelectrolyte complexes (PECs) with potential application as wound dressing biomaterials. For that purpose, different amounts of poly(dimethylsiloxane) were incorporated during the formulation of the PECs. Results showed that the highest tensile strength was observed when using 0.1 g of poly(dimethylsiloxane) per gram of PEC (CAS10). This formulation was also non-hemolytic, capable of inducing thrombus formation to potentially reduce bleeding, and additionally presented high stability when exposed to...
Authors: Szarpak L Abstract INTRODUCTION: According to the American Society of Anesthesiologists, the incidence of difficult intubation in the operating room is 1.2-3.8%; however, in emergency conditions, this rate is higher and reaches even 5.3%. Successful emergency airway management is an essential component of the modern practice of medicine. Areas covered: The aim of the study is to review the literature regarding different devices used to perform endotracheal intubation (Macintosh, Miller, and McCoy laryngoscopes; ETView, GlideScope, TruView, Airtraq, McGrath MAC, Pentax AWS, Trachlight, Shikani, and Bullard)...
Conclusions: This study demonstrated significant in vivo supraspinatus tenotoxicity following a single injection of combination local anesthetic/ corticosteroid when compared to saline controls. Level of Evidence: Level II. PMID: 30104932 [PubMed - in process]
Conclusion: This study suggests that FSB may be a more effective pain management technique for reducing the total IV morphine equivalent dose, maximum NRS pain scores, number of PACU postoperative opioid doses, and PACU LOS following ACL reconstruction in the pediatric population.Level of Evidence: III. PMID: 30104931 [PubMed - in process]
Some significant benefits observed in quality of life domains for patients with newly diagnosed HNC
Expert panel recommends five action steps for treating opioid abuse and its intersecting epidemics
Authors: Davies GAL, Maxwell C, McLeod L Abstract OBJECTIVE: To review the evidence and provide recommendations for the counselling and management of obese parturients. OUTCOMES: Outcomes evaluated include the impact of maternal obesity on the provision of antenatal and intrapartum care, maternal morbidity and mortality, and perinatal morbidity and mortality. EVIDENCE: Literature was retrieved through searches of Statistics Canada, Medline, and The Cochrane Library on the impact of obesity in pregnancy on antepartum and intrapartum care, maternal morbidity and mortality, obstetrical anaesthesia, and perinat...
This study tested and compared the heating capabilities of three small fluid warming systems. Are they as effective as full-size units at maintaining stable heating?BMC Anesthesiology
Conditions: Hand Surgery; Quality of Recovery; Hand Injuries; Hand Fracture; Hand Tendon Injury; Anesthesia, Local Intervention: Procedure: Local anesthesia with minimal sedation Sponsor: McGill University Health Center Not yet recruiting
Condition: Anesthesia Intubation Complication Intervention: Drug: Ketamine Sponsor: University Hospital, Mahdia Recruiting