Effect of melatonin on cytokine levels in a hyperthermia-induced febrile seizure model.
In this study, we investigated serum cytokine levels in a hyperthermia-induced febrile rat seizure model and the effect of melatonin. A total of 28 male Sprague-Dawley rats were divided into four groups: the control (C) group, healthy melatonin (MT) group, and hyperthermia-induced febrile seizure groups with (HIFS-MT) and without (HIFS) administration of melatonin. Melatonin (80 mg/kg) was given intraperitoneally 15 min before the seizure. HIFS was induced by placing the rats in 45°C water. The rats were sacrificed under anesthesia after the seizure. Blood samples were drawn by transcardiac puncture to measure serum cytokine and melatonin levels. Serum interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α levels were lower in the HIFS group than those in the C group (p = 0.005, p = 0.200, p = 0.011, and p = 0.016, respectively). All serum cytokine levels of rats in the MT and HIFS-MT groups were similar to those in the C group. This experimental rat model demonstrated that serum cytokine levels decrease with HIFS and that administering melatonin maintains serum cytokine levels. These results suggest that cytokines may play role in the anticonvulsive activity of melatonin in rats with febrile seizures. PMID: 29208169 [PubMed - in process]
This review summarizes the latest evidence on the genetics of malignant hyperthermia susceptibility, guidelines for genetic diagnosis, and the limitations of current genetic screening.Anesthesiology
Publication date: Available online 16 February 2018 Source:Journal of Pharmacological Sciences Author(s): Kaori Takahashi, Daisuke Nishizawa, Shinya Kasai, Yoshihiko Koukita, Ken-ichi Fukuda, Tatsuya Ichinohe, Kazutaka Ikeda Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage genome-wide association study in subjects who were scheduled to undergo mandibular sagitt...
Conclusions Plants of this genus have provided bioactive species, both from crude extracts and pure compounds thus substantiating their efficacy in traditional medicine. In vivo and toxicological studies are still limited, but the results of different activities of Piper reported point out the great potential of these species for obtaining bioactive principles that may be useful in treating diseases. However, a thorough investigation of Piper species relating to chemistry, in vivo pharmacological activities, with emphasis on their mechanism of action, safety and efficacy and toxicity is warranted.
This article is protected by copyright. All rights reserved. Interaction between the infralimbic region of the medial prefrontal cortex (IL) and the central nucleus of the amygdala (CeA) is critical in the stress processes. After the electrical activation of the CeA in urethane‐anesthetised rats, by mimicking firing rates induced by acute stress, a delayed particular slow wave in the IL local field potential, in association with theta, gamma and spindles oscillations, was observed. In addition, this slow oscillation was accompanied by an increase in theta‐gamma coupling. This characteristic oscillatory pattern might b...
Researchers at The University of Wisconsin-Madison linked anesthesia with a slight decline in memory. The findings were published in the journal Anaesthesia.
CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that for a 64-slice CT scanner, the optimal protocol for the acquisition of CT images of the dentition in alpacas was a sequential scan with a slice thickness of 1.25 mm. PMID: 29466047 [PubMed - in process]
CONCLUSIONS AND CLINICAL RELEVANCE Damage to the brainstem and key adjacent structures may be accomplished by firing a PCB perpendicular to the skull over the anatomic site identified at the intersection of 2 lines, each drawn from the lateral canthus of 1 eye to the middle of the base of the opposite ear. PMID: 29466040 [PubMed - in process]
Access Vascular, a company based in Bedford, MA that makes a novel material for preventing the clogging up of catheters, won FDA clearance for its HydroPICC catheter. The company’s “bulk-hydrophilic” material is rich in water and ca...
Learn about different causes of upper thigh pain, from injuries to nerve problems. We look at the associated symptoms and treatment options.
Condition: Topical Anesthesia Interventions: Drug: Lidocaine + Prilocaine; Drug: Lidocaine; Drug: Prilocaine Sponsors: Galeno Desenvolvimento de Pesquisas Clínicas; Biolab Sanus Farmaceutica Completed