Effect of melatonin on cytokine levels in a hyperthermia-induced febrile seizure model.
In this study, we investigated serum cytokine levels in a hyperthermia-induced febrile rat seizure model and the effect of melatonin. A total of 28 male Sprague-Dawley rats were divided into four groups: the control (C) group, healthy melatonin (MT) group, and hyperthermia-induced febrile seizure groups with (HIFS-MT) and without (HIFS) administration of melatonin. Melatonin (80 mg/kg) was given intraperitoneally 15 min before the seizure. HIFS was induced by placing the rats in 45°C water. The rats were sacrificed under anesthesia after the seizure. Blood samples were drawn by transcardiac puncture to measure serum cytokine and melatonin levels. Serum interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α levels were lower in the HIFS group than those in the C group (p = 0.005, p = 0.200, p = 0.011, and p = 0.016, respectively). All serum cytokine levels of rats in the MT and HIFS-MT groups were similar to those in the C group. This experimental rat model demonstrated that serum cytokine levels decrease with HIFS and that administering melatonin maintains serum cytokine levels. These results suggest that cytokines may play role in the anticonvulsive activity of melatonin in rats with febrile seizures. PMID: 29208169 [PubMed - in process]
CONCLUSION: Tongue base mucosectomy using electrocautery and conventional tonsillectomy equipment is a safe, effective technique in the identification of cervical metastasis from an unknown primary site. It expands the potential breadth of use, quickens prolonged diagnostic pathways and obviates the necessity for pan-mucosal irradiation. PMID: 30457073 [PubMed - as supplied by publisher]
Authors: Hirose T, Funasaka K, Furukawa K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Miyahara R, Hirooka Y Abstract Plummer-Vinson syndrome is a rare entity, characterized by dysphagia, esophageal web formation, and iron deficiency anemia. The patient was a 63-year-old woman with a clinical history of iron deficiency anemia and glossitis in her 20s to 40s and who had experienced swallowing difficulties for the past 20 years. A membranous stricture was found in the cervical esophagus during a fluoroscopic examination. An endoscopic examination conducted under general anesthesia revealed an oblique lin...
Publication date: Available online 20 November 2018Source: Neuroscience LettersAuthor(s): P.A. Kirkwood, JR Romaniuk, KE KowalskiAbstractPrevious analyses of recordings of alpha motoneuron discharges from branches of the intercostal and abdominal nerves in anesthetized cats under neuromuscular blockade demonstrated modulation with the cardiac cycle. This modulation was interpreted as evidence that thoracic somatosensory afferents, most likely muscle spindles, provide a signal to the CNS that could contribute to cardiac interoception. Here, two aspects of these observations have been extended. First, new measurements of tho...
ConclusionsThe confluence of design between the animal holder and RF coil provides a pragmatic solution for routine imaging of small animals.
CONCLUSION: miR-34a inhibitor may effectively protect against sevoflurane-induced hippocampal apoptosis via activation of the Wnt/β-catenin pathway by targeting Wnt1. PMID: 30450855 [PubMed - in process]
Abstract The prevalence of adult congenital heart disease (ACHD) is increasing due to advances in surgical techniques, anesthesia, and perioperative care. Imaging plays an important role, not only in the surveillance of ACHD, but also in the initial evaluation of cases that have escaped detection early in life and present with symptoms later in adulthood. In this article, we review the role of computed tomography in the comprehensive evaluation of ACHD. PMID: 30454820 [PubMed - in process]
Abstract Congenital abnormalities of the thoracic aorta encompass a variety of disorders with variable clinical manifestations ranging from asymptomatic to life threatening. A variety of imaging modalities are available for the evaluation of these anomalies with computed tomography (CT) commonly preferred due to its excellent spatial resolution and rapid acquisitions, avoiding the need of general anesthesia or even sedation. We review the embryology, imaging findings, and associations of multiple congenital thoracic aorta malformations with emphasis in the role of CT angiography in the evaluation of these patholog...
App can cut both severity of advanced cancer patients'reported pain and hospital admissions
Condition: Radial Fracture Intervention: Procedure: Short or long-acting local anesthetic or general anesthesia Sponsor: Sahlgrenska University Hospital, Sweden Recruiting
Conditions: Anesthesia; Cell Phone; Mobile Applications Intervention: Other: questionary Sponsor: Universitair Ziekenhuis Brussel Not yet recruiting